Botanical species · safety record

Hydrastis canadensis

The EFSA Compendium of Botanicals holds 25 constituent measurements and 8 adverse-effect records for Hydrastis canadensis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Hydrastis canadensis L.

25Constituent measurements

8Safety records

8Cited sources

665Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 665 licensed products naming Hydrastis canadensis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid
solid

Source material stated

Aerial parts
Dried aerial part(s)
Dried root and rhizome
Dried root(s)
Dried roots & root crowns
Dried underground part(s)
Dried underground parts
Goldenseal

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Alkaloids	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Alkaloids	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Alkaloids	Roots and other underground parts	—	6.86 Percent	Unspecified	Resolve DOI
Berberine	Roots and other underground parts	—	3.89 Percent	Unspecified	Resolve DOI
Berberine	Roots and other underground parts	Solvent extraction	1.9 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Berberine	Roots and other underground parts	Solvent extraction	2.52 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Berberine	Roots and other underground parts	—	3.89 Percent	Unspecified	Resolve DOI
Canadine	Roots and other underground parts	—	0.17 Percent	Unspecified	Resolve DOI
Canadine	Roots and other underground parts	—	0.17 Percent	Unspecified	Resolve DOI
Canadine	Roots and other underground parts	Solvent extraction	0.06 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Canadine	Roots and other underground parts	Solvent extraction	0.04 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Hydrastine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Hydrastine	Roots and other underground parts	—	2.8 Percent	Unspecified	Resolve DOI
Hydrastine	Roots and other underground parts	—	2.8 Percent	Unspecified	Resolve DOI
Hydrastine	Roots and other underground parts	Solvent extraction	1.3 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Hydrastine	Roots and other underground parts	Solvent extraction	1.38 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Hydrastinine	Roots and other underground parts	Solvent extraction	< 0.06 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Palmatine	Roots and other underground parts	Solvent extraction	0.1 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Palmatine	Roots and other underground parts	Solvent extraction	0.22 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Berberine	Roots and other underground parts	Solvent extraction	≤ 3.45 Percent	HPLC-UV	No resolvable identifier
Berberine	Roots and other underground parts	Solvent extraction	≥ 2.79 Percent	HPLC-UV	No resolvable identifier
Hydrastine	Roots and other underground parts	Solvent extraction	≤ 4.05 Percent	HPLC-UV	No resolvable identifier
Hydrastine	Roots and other underground parts	Solvent extraction	≥ 2.24 Percent	HPLC-UV	No resolvable identifier
Isoquinoline alkaloids	Roots and other underground parts	—	—	—	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Unspecified	—	House mouse (as animal)	Subchronic	Resolve DOI
Hepatotoxicity	Liver	Unspecified	—	Rat (as animal)	Subchronic	Resolve DOI
Hepatotoxicity	Liver	Roots and other underground parts	—	Rat (as animal)	Case report	Resolve DOI
Hepatotoxicity	Liver	Roots and other underground parts	—	House mouse (as animal)	Case report	Resolve DOI
Hepatotoxicity	Liver	Unspecified	—	House mouse (as animal)	Subchronic	No resolvable identifier
Hepatotoxicity	Liver	Unspecified	—	House mouse (as animal)	Subchronic	No resolvable identifier
Hepatotoxicity	Liver	Unspecified	—	Rat (as animal)	Subchronic	No resolvable identifier
Hepatotoxicity	Liver	Unspecified	—	Rat (as animal)	Subchronic	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Dunnick, June K., Singh, Bhanu., Nyska, Abraham., Peckham, John., Kissling, Grace E., Sanders, J. Michael. Investigating the Potential for Toxicity from Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle . Toxicologic pathology, 2011, vol. 39, no. 2, p. 398-409. DOI
Dunnick, June K., Nyska, Abraham. The Toxicity and Pathology of Selected Dietary Herbal Medicines. Toxicologic pathology, 2013, vol. 41, no. 2, p. 374-386. DOI
Toxicology and carcinogenesis studies of goldenseal root powder (Hydrastis Canadensis) in F344/N rats and B6C3F1 mice (feed studies). . National toxicology program technical report series, 2010, no. 562, p. 1-188.
Brown, Paula N., Roman, Mark C. Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: Collaborative study . Journal of aoac international, 2008, vol. 91, no. 4, p. 694-701.
Weber, HA., Zart, MK., Ferguson, SL., Greaves, JG., Clark, AP., Harris, RK., Overstreet, D., Smith, C. Separation and quantitation of isoquinoline alkaloids occurring in goldenseal . Journal of liquid chromatography & related technologies, 2001, vol. 24, no. 1, p. 87-95. DOI
Inbaraj, J. J., Kukielczak, B. M., Bilski, P., He, Y. -Y., Sik, R. H., Chignell, C. F. Photochemistry and photocytotoxicity of alkaloids from goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine . Chemical research in toxicology, 2006, vol. 19, no. 6, p. 739-744. DOI
Avula, Bharathi., Wang, Yan-Hong., Khan, Ikhlas A. Quantitative Determination of Alkaloids from Roots of Hydrastis canadensis L. and Dietary Supplements Using Ultra-Performance Liquid Chromatography with UV Detection . Journal of aoac international, 2012, vol. 95, no. 5, p. 1398-1405. DOI
Messana, Irene., La Bua, Roberto., Galeffi, Corrado. The alkaloids of Hydrastis canadensis L. (Ranunculaceae). Two new alkaloids: hydrastidine and isohydrastidine. Gazzetta chimica italiana, 1980, vol. 110(9-10), p. 539-43.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature