Botanical species · safety record

Hypericum maculatum

The EFSA Compendium of Botanicals holds 25 constituent measurements for Hypericum maculatum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Hypericum maculatum Crantz

25Constituent measurements

0Safety records

7Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
(-)-globulol	Aerial part of plants	Essential oil	≤ 8 Percent	GC-MS	Resolve DOI
(-)-globulol	Aerial part of plants	Essential oil	≥ 0.1 Percent	GC-MS	Resolve DOI
Emodin	Leaves	Solvent extraction	0.3 Microgram/gram	LC-MS/MS	Resolve DOI
Hyperforin	Live plants	Solvent extraction	≥ 266 Microgram/gram	LC-MS/MS	Resolve DOI
Hyperforin	Aerial part of plants	Solvent extraction	≤ 0.49 Percent	HPLC-DAD	Resolve DOI
Hyperforin	Aerial part of plants	Solvent extraction	≥ 0.13 Percent	HPLC-DAD	Resolve DOI
Hyperforin	Live plants	Solvent extraction	≤ 2449 Microgram/gram	LC-MS/MS	Resolve DOI
Hypericin	Aerial part of plants	Solvent extraction	≥ 0.07 Percent	HPLC-DAD	Resolve DOI
Hypericin	Aerial part of plants	Solvent extraction	≤ 0.15 Percent	HPLC-DAD	Resolve DOI
Hypericin	Aerial part of plants	Solvent extraction	≤ 84 Microgram/gram	LC-MS/MS	Resolve DOI
Hypericin	Aerial part of plants	Solvent extraction	≥ 3 Microgram/gram	LC-MS/MS	Resolve DOI
Isoquercitrin	Aerial part of plants	Solvent extraction	≥ 0.87 Percent	HPLC-DAD	Resolve DOI
Isoquercitrin	Aerial part of plants	Solvent extraction	≤ 0.88 Percent	HPLC-DAD	Resolve DOI
Pseudohypericin	Aerial part of plants	Solvent extraction	≥ 0.16 Percent	HPLC-DAD	Resolve DOI
Pseudohypericin	Aerial part of plants	Solvent extraction	≤ 0.19 Percent	HPLC-DAD	Resolve DOI
Pseudohypericin	Aerial part of plants	Solvent extraction	≥ 17 Microgram/gram	LC-MS/MS	Resolve DOI
Pseudohypericin	Aerial part of plants	Solvent extraction	≤ 318 Microgram/gram	LC-MS/MS	Resolve DOI
Hypericin	Flowering top	—	0.02 Percent	—	No resolvable identifier
Hypericin	Aerial part of plants	Solvent extraction	≤ 0.74 Gram/100 gram	LC-MS	No resolvable identifier
Hypericin	Aerial part of plants	Solvent extraction	≥ 0.12 Gram/100 gram	LC-MS	No resolvable identifier
Isoquercitrin	Aerial part of plants	Solvent extraction	244.59 Milligram/100 gram	LC-MS	No resolvable identifier
Phloroglucinol derivatives	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Pseudohypericin	Flowering top	—	0.11 Percent	—	No resolvable identifier
Tannins	Aerial part of plants	—	≤ 13.52 Percent	Unspecified	No resolvable identifier
Tannins	Aerial part of plants	—	≥ 12.1 Percent	Unspecified	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Rusalepp, Linda., Raal, Ain., Puessa, Tonu., Maeeorg, Uno. Comparison of chemical composition of Hypericum perforatum and H-maculatum in Estonia . Biochemical systematics and ecology, 2017, vol. 73, p. 41-46. DOI
Smelcerovic, Andrija., Spiteller, Michael., Ligon, Axel Patrick., Smelcerovic, Zaklina., Raabe, Nils. Essential oil composition of Hypericum L. species from Southeastern Serbia and their chemotaxonomy . Biochemical systematics and ecology, 2007, vol. 35, no. 2, p. 99-113. DOI
Kusari, Souvik., Zuehlke, Sebastian., Borsch, Thomas., Spiteller, Michael. Positive correlations between hypericin and putative precursors detected in the quantitative secondary metabolite spectrum of Hypericum . Phytochemistry, 2009, vol. 70, no. 10, p. 1222-1232. DOI
Girzu-Amblard, M., Carnat, A., Fraisse, D., Carnat, A.-P., Lamaison, J.-L. Flavonoid and dianthranoid levels of the St.-John's-wort flowering tops. Annales pharmaceutiques francaises, 2000, vol. 58, no. 5, p. 341-345.
Oniga, Ilioara., Toiu, Anca., Benedec, Daniela., Tomuta, Ioan., Vlase, Laurian. PHYTOCHEMICAL ANALYSIS OF HYPERICUM MACULATUM IN ORDER TO OBTAIN STANDARDIZED EXTRACTS . Farmacia, 2016, vol. 64, no. 2, p. 171-174.
Polezhaeva, N. S., Kanyuchkova, G. K. Content of flavonoids, tannins, and carotenoids in Hypericum maculatum Crantz. Rastitel'nye resursy, 1985, vol. 21, no. 3, p. 340-3.
Nedialkov, Paraskev T., Momekov, Georgi., Kokanova-Nedialkova, Zlatina K., Heilmann, Joerg. Polyprenylated Phloroglucinols from Hypericum maculatum. Natural product communications, 2015, vol. 10, no. 7, p. 1231-1235.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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