Botanical species · safety record

Hypericum perforatum

The EFSA Compendium of Botanicals holds 3 constituent measurements, 4 adverse-effect records and 1 genotoxicity assay for Hypericum perforatum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Hypericum perforatum L.

3Constituent measurements

5Safety records

4Cited sources

546Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 546 licensed products naming Hypericum perforatum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid

Source material stated

Aerial part with flowers
Aerial parts
Aerial parts with flowers
Dried aerial part(s)
Dried herb tops
Flower
Flower (standardized extract)
Flower and stem

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Hyperforin	—	—	≥ 2 Percent	Unspecified	Resolve DOI
Hypericin	—	—	0.09 Percent	Unspecified	Resolve DOI
Pseudohypericin	—	—	0.23 Percent	Unspecified	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Irritation	—	Live plants	Drying (dehydration)	Horse (as animal)	Case report	Resolve DOI
Neurotoxicity	Neurologic: central nervous system	—	Solvent extraction	Human (as organism)	In vitro	Resolve DOI
Other toxicities	Skin/subcutis	—	—	Human (as organism)	Acute toxicity	Resolve DOI
Other toxicities	Skin/subcutis	—	—	Human (as organism)	Acute toxicity	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	subchronic	House mouse (as animal)	—	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Caloni, F., Cortinovis, C. Plants poisonous to horses in Europe. Equine veterinary education, 2015, vol. 27, no. 5, p. 269-274. DOI
Rietjens, IMCM., Martena, MJ., Boersma, MG., Spiegelenberg, W., Alink, GM. Molecular mechanisms of toxicity of important food-borne phytotoxins. Molecular nutrition & food research, 2005, vol. 49, no. 2, p. 131-158. DOI
Qureshi, Shoeb. Studies on the cytological, biochemical and reproductive toxicity of St. Johna's Wort after chronic treatment in swiss albino mice. American-eurasian journal of toxicological sciences, 2013, vol. 97-103, p. 7.
Jacobson, JM., Feinman, L., Liebes, L., Ostrow, N., Koslowski, V., Tobia, A., Cabana, BE., Lee, DH., Spritzler, J., Prince, AM. Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's Wort plant, in patients with chronic hepatitis C virus infection. Antimicrobial agents and chemotherapy, 2001, vol. 45, no. 2, p. 517-524. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature