Botanical species · safety record

Illicium anisatum

The EFSA Compendium of Botanicals holds 7 constituent measurements and 6 adverse-effect records for Illicium anisatum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Illicium anisatum L.

7Constituent measurements

6Safety records

10Cited sources

21Licensed products (Canada)

Also recorded as

Illicium religiosum Siebold & Zucc.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 21 licensed products naming Illicium anisatum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Dried fruit
Grain(s)
Graine
New material
Seed
Seed(s)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Anisatin	Seed	Solvent extraction	477 Milligram/kilogram	LC-MS/MS	Resolve DOI
Anisatin	Seed	Raw, no heat treatment	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Neoanisatin	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Pseudoanisatin	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Sesquiterpene lactones	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Anisatin	Fruit unspecified	—	—	—	No resolvable identifier
Diterpene lactones	Seed	Solvent extraction	—	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Respiratory	Fruit unspecified	Solvent extraction	Human (as organism)	Acute toxicity	Resolve DOI
Neurotoxicity	Neurologic: central nervous system	Seed	Solvent extraction	Human (as organism)	Case report	Resolve DOI
Nephrotoxicity	Neurologic: central nervous system	Unspecified	—	Dog (as animal)	Acute toxicity	No resolvable identifier
Neurotoxicity	Neurologic: central nervous system	Seed	—	Human (as organism)	Case report	No resolvable identifier
Neurotoxicity	Neurologic: central nervous system	Fruit unspecified	Solvent extraction	Human (as organism)	Acute toxicity	No resolvable identifier
Neurotoxicity	Neurologic: central nervous system	Seed	Solvent extraction	Cat (as animal)	Acute toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Chen, K. K. A study of Illicium religiosum. Journal of the american pharmaceutical association (1912-1977), 1926, vol. 15, p. 861-5.
CALDWELL, A F., BARNES, J. An occurrence of toxic convulsions due to poisoning with Illicium religiosum. . Journal of the royal army medical corps, 1957, vol. 103, no. 2, p. 91-4.
Guerrero Fern�ndez, J., Tagarro Garc�a, A., Valle S�nchez, A., Garc�a Aparicio, J., Garc�a Garc�a, S. Nine cases of poisoning by star anise Nueve casos de intoxicaci�n por an�s estrellado . Revista espanola de pediatria, 2002, vol. 58, no. 344, p. 111-114.
Perret, C., Tabin, R., Marcoz, J. -P., Llor, J., Cheseaux, J. -J. Apparent life-threatening event in infants: Think about star anise intoxication! . Archives de pediatrie, 2011, vol. 18, no. 7, p. 750-753. DOI
Chou, T. Q. Sikimitoxin, the toxic principle of Illicium religiosum, Sieb. (Mang-t'sao). Zhongguo shenglixue zazhi, 1927, vol. 1, p. 213-8.
Ize-Ludlow, D., Ragone, S., Bruck, IS., Bernstein, JN., Duchowny, M., Pena, BMG. Neurotoxicities in infants seen with the consumption of star anise tea. Pediatrics, 2004, vol. 114, no. 5, p. E653-E656. DOI
Mathon, Caroline., Bongard, Benjamin., Duret, Monique., Ortelli, Didier., Christen, Philippe., Bieri, Stefan. Analysis of the neurotoxin anisatin in star anise by LC-MS/MS. EXPOSURE & RISK ASSESSMENT, 2013, vol. 30, no. 9, p. 1598-1605. DOI
Kawano, Nobusuke., Matsuo, Akemi. Toxic components of Illicium anisatum. I. Yakugaku zasshi, 1958, vol. 78, p. 1220-3.
KOUNO, I., MORI, K., AKIYAMA, T., HASHIMOTO, M. 2 SESQUITERPENE LACTONES FROM ILLICIUM-ANISATUM. Phytochemistry, 1991, vol. 30, no. 1, p. 351-353. DOI
Schrage, Marijn., Shen, Yao., Claassen, Frank W., Zuilhof, Han., Nielen, Michel W. F., Chen, Bo., van Beek, Tens A. Rapid and simple neurotoxin-based distinction of Chinese and Japanese star anise by direct plant spray mass spectrometry . Journal of chromatography a, 2013, vol. 1317, p. 246-253. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature