Botanical species · safety record

Isocoma pluriflora

The EFSA Compendium of Botanicals holds 14 constituent measurements and 4 adverse-effect records for Isocoma pluriflora. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Isocoma pluriflora (Torr. & A.Gray) Greene

14Constituent measurements

4Safety records

5Cited sources

0Licensed products (Canada)

Also recorded as

Haplopappus heterophyllus (A.Gray) S.F.Blake

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
3-oxyangeloyl-tremetone	Aerial part of plants	Solvent extraction	≥ 1.9 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
3-oxyangeloyl-tremetone	Aerial part of plants	Solvent extraction	≤ 4 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
3-oxyangeloyl-tremetone	Aerial part of plants	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
3-oxyangeloyl-tremetone	Live plants	Solvent extraction	2.39 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Dehydrotremetone	Live plants	Solvent extraction	1.34 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Dehydrotremetone	Aerial part of plants	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Dehydrotremetone	Aerial part of plants	Solvent extraction	≤ 2.6 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Dehydrotremetone	Aerial part of plants	Solvent extraction	≥ 0.8 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Tremetone	Live plants	Solvent extraction	0.53 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Tremetone	Aerial part of plants	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Tremetone	Aerial part of plants	Solvent extraction	≤ 0.4 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Tremetone	Aerial part of plants	Solvent extraction	≥ 0.16 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Benzofurans	Live plants	Solvent extraction	—	Chromatographic tests	No resolvable identifier
Carvone	Live plants	Solvent extraction	—	Chromatographic tests	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Musclo-skeletal	Muscle, skeletal	—	—	Goat (as animal)	Short-term toxicity	Resolve DOI
Pulmonary and cardiac	Heart	—	—	Horse (as animal)	Short-term toxicity	Resolve DOI
Pulmonary and cardiac	Heart	—	—	Goat (as animal)	Short-term toxicity	Resolve DOI
Pulmonary and cardiac	Heart	—	—	Horse (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Zalkow, L. H., Ekpo, B. A., Gelbaum, L. T., Harris, R. N., III., Keinan, E., Novak, J. R., Jr., Ramming, C. T., Van Derveer, D. The benzofurans of Isocoma wrightii. Structure and stereochemistry. Journal of Natural Products, 1979, p. 203-219.
Davis, T. Z., Stegelmeier, B. L., Lee, S. T., Green, B. T., Hall, J. O. Experimental rayless goldenrod (Isocoma pluriflora) toxicosis in horses. TOXICON, 2013, vol. 73, p. 88-95. DOI
Davis, T. Zane., Green, Benedict T., Stegelmeier, Bryan L., Lee, Stephen T., Welch, Kevin D., Pfister, James A. Physiological and serum biochemical changes associated with rayless goldenrod (Isocoma pluriflora) poisoning in goats. TOXICON, 2013, vol. 76, p. 247-254. DOI
Lee, Stephen T., Cook, Daniel., Davis, T. Zane., Gardner, Dale R., Johnson, Robert L., Stonecipher, Clinton A. A Survey of Tremetone, Dehydrotremetone, and Structurally Related Compounds in Isocoma spp. (Goldenbush) in the Southwestern United States . Journal of agricultural and food chemistry, 2015, vol. 63, no. 3, p. 872-879. DOI
Zalkow, L.H., Harris III, R.N., Burke, N.I. The lower terpenoids of Isocoma Wrightii. Journal of Natural Products, 1979, p. 96-102.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature