Botanical species · safety record

Jacobaea vulgaris

The EFSA Compendium of Botanicals holds 7 constituent measurements, 3 adverse-effect records and 1 genotoxicity assay for Jacobaea vulgaris. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Jacobaea vulgaris Gaertn.

7Constituent measurements

4Safety records

6Cited sources

0Licensed products (Canada)

Also recorded as

Senecio jacobaea L.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Pyrrolizidine alkaloids	Unspecified	Solvent extraction	≥ 74.6 Microgram/millilitre	LC-MS/MS	Resolve DOI
Pyrrolizidine alkaloids	Unspecified	Solvent extraction	≤ 1382.9 Microgram/millilitre	LC-MS/MS	Resolve DOI
Pyrrolizidine alkaloids	Pollen-related	Solvent extraction	≤ 800 Microgram/gram	HPLC with standard detection methods	Resolve DOI
Pyrrolizidine alkaloids	Pollen-related	Solvent extraction	≥ 100 Microgram/gram	HPLC with standard detection methods	Resolve DOI
Pyrrolizidine alkaloids	Live plants	Solvent extraction	2339 Milligram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Pyrrolizidine alkaloids	Aerial part of plants	—	0.18 Percent	—	Resolve DOI
Pyrrolizidine alkaloids	Aerial part of plants	—	0.135 Percent	—	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Aerial part of plants	Drying (dehydration)	Gallus gallus (chicken) (as animal)	Short-term toxicity	Resolve DOI
Hepatotoxicity	Liver	Aerial part of plants	Drying (dehydration)	Horse (as animal)	Short-term toxicity	Resolve DOI
Hepatotoxicity	Neurologic: central nervous system	Live plants	Drying (dehydration)	Sheep (as animal)	Short-term toxicity	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

HUAN, JY., CHEEKE, PR., LOWRY, RR., NAKAUE, HS., SNYDER, SP., WHANGER, PD. DIETARY PYRROLIZIDINE (SENECIO) ALKALOIDS AND TISSUE DISTRIBUTION OF COPPER AND VITAMIN-A IN BROILER-CHICKENS. TOXICOLOGY LETTERS, 1992, vol. 62, no. 2-3, p. 139-153. DOI
CRAIG, AM., PEARSON, EG., MEYER, C., SCHMITZ, JA. CLINICOPATHOLOGICAL STUDIES OF TANSY RAGWORT TOXICOSIS IN PONIES - SEQUENTIAL SERUM AND HISTOPATHOLOGICAL CHANGES . Journal of equine veterinary science, 1991, vol. 11, no. 5, p. 261-&. DOI
Bovee, Toine F. H., Helsdingen, Richard J. R., Hoogenboom, Ron L. A. P., de Nijs, Monique W. C. M., Liu, Xiaojie., Vrieling, Klaas., Klinkhamer, Peter G. L., Peijnenburg, Ad A. C. M., Mulder, Patrick P. J. Are effects of common ragwort in the Ames test caused by pyrrolizidine alkaloids? . Mutation research-fundamental and molecular mechanisms of mutagenesis, 2015, vol. 778, p. 1-10. DOI
Boppre, Michael., Colegate, Steven M., Edgar, John A., Fischer, Ottmar W. Hepatotoxic pyrrolizidine alkaloids in pollen and drying-related implications for commercial processing of bee pollen. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, vol. 56, no. 14, p. 5662-5672. DOI
Hoogenboom, L. A. P., Mulder, P. P. J., Zeilmaker, M. J., van den Top, H. J., Remmelink, G. J., Brandon, E. F. A., Klijnstra, M., Meijer, G. A. L., Schothorst, R., Van Egmond, H. P. Carry-over of pyrrolizidine alkaloids from feed to milk in dairy cows. Food additives and contaminants part a-chemistry analysis control exposure & risk assessment, 2011, vol. 28, no. 3, p. 359-372. DOI
Hooper, P.T. Spongy degeneration in the central nervous system of domestic animals - Part III: Occurrence and pathogenesis -Hepatocerebral disease caused by hyperammonaemia. Acta neuropathologica, 1975, vol. 31, no. 4, p. 343-351. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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