Botanical species · safety record

Jatropha gossypiifolia

The EFSA Compendium of Botanicals holds 6 constituent measurements, 10 adverse-effect records and 1 genotoxicity assay for Jatropha gossypiifolia. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Jatropha gossypiifolia L.

6Constituent measurements

11Safety records

10Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Coumarins	Fruit unspecified	—	—	Unspecified	Resolve DOI
Diterpene ketones	Fruit unspecified	—	—	Unspecified	Resolve DOI
Lignans	Fruit unspecified	—	—	Unspecified	Resolve DOI
Jatrophone	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Tannins	Leaves	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Aerial part of plants	Solvent extraction	Rat (as animal)	Chronic/long term toxicity	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Aerial part of plants	Solvent extraction	Rat (as animal)	Chronic/long term toxicity	Resolve DOI
Neurotoxicity	Neurologic	Aerial part of plants	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Neurotoxicity	Neurologic	Aerial part of plants	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Pulmonary and cardiac	Heart	Aerial part of plants	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Pulmonary and cardiac	Lung	Aerial part of plants	Solvent extraction	Rat (as animal)	Chronic/long term toxicity	Resolve DOI
Pulmonary and cardiac	Heart	Aerial part of plants	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Reproductive	Urogenital	Leaves	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Systemic	—	Aerial part of plants	Solvent extraction	Rat (as animal)	Chronic/long term toxicity	Resolve DOI
Systemic	Heart	Leaves	Fresh	Sheep (as animal)	Acute toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	micronucleus assay	Other	No data	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Oliveira, L.I., Jabour, F.F., Nogueira, V.A., Yamasaki, E.M. Experimental poisoning by the leaves of Jatropha gossypifolia (Euphorbiaceae) in sheep Intoxica��o experimental com as folhas de Jatropha gossypifolia (Euphorbiaceae) em ovinos . Pesquisa veterinaria brasileira, 2008, vol. 28, no. 6, p. 275-278.
Abreu, IC., Marinho, ASS., Paes, AMA., Freire, SMF., Olea, RSG., Borges, MOR., Borges, ACR. Hypotensive and vasorelaxant effects of ethanolic extract from Jatropha gossypiifolia L. in rats . Fitoterapia, 2003, vol. 74, no. 7-8, p. 650-657. DOI
Mariz, Saulo R., Cerqueira, Gilberto S., Araujo, Washington C., Dantas, Jadson G., Ramalho, Josue A., Palomaro, Thayse V., Duarte, Jose C., dos Santos, Hosana B., Olveira, Kardilandia., de Araujo, Maria Salete T., Diniz, Margareth de F. F. M., de Medeiros, Isac A. Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2012, vol. 22, no. 3, p. 663-668. DOI
Mariz, Saulo R., Cerqueira, Gilberto S., Ara�jo, Washington C., Duarte, Jos� C., Melo, Arquimedes F.M., Santos, Hosana B., Oliveira, Kardil�ndia., Diniz, Margareth F.F. Melo., Medeiros, Isac A. Estudo toxicol�gico agudo do extrato etan�lico de partes a�reas de Jatropha gossypiifolia L. em ratos . Revista brasileira de farmacognosia, 2006, vol. 16, no. 3, p. 372-378. DOI
Jain, S., Choudhary, G.P., Jain, D.K. Pharmacological evaluation of anti-fertility activity of ethanolic extract of Jatropha gossypifolia leaf in female albino mice. Asian pacific journal of tropical biomedicine, 2012, vol. 2, no. 3 SUPPL., p. S1671-S1674. DOI
Zhang, X.-P., Zhang, M.-L., Su, X.-H., Huo, C.-H., Gu, Y.-C., Shi, Q.-W. Chemical constituents of the plants from genus Jatropha. Chemistry and biodiversity, 2009, vol. 6, no. 12, p. 2166-2183. DOI
Coe, F.G., Parikh, D.M., Johnson, C.A. Alkaloid presence and brine shrimp (Artemia salina) bioassay of medicinal species of eastern Nicaragua. Pharmaceutical Biology, 2010, vol. 48, no. 4, p. 439-445. DOI
Singh, P., Dabas, A., Srivastava, R., Nagpure, N.S., Singh, A. Evaluation of genotoxicity induced by medicinal plant Jatropha gossypifolia in freshwater fish Channa punctatus (Bloch). Turkish Journal of Fisheries and Aquatic Sciences, 2014, vol. 14, no. 2, p. 421-428. DOI
Kupchan, S. Morris., Sigel, Carl W., Matz, Marilyn J., Gilmore, Christopher J., Bryan, Robert F. Tumor inhibitors. 111. Structure and stereochemistry of jatrophone, a novel macrocyclic diterpenoid tumor inhibitor. Journal of the American Chemical Society, 1976, p. 2295-2300.
Felix-Silva, Juliana., Souza, Thiago., Menezes, Yamara A. S., Cabral, Barbara., Camara, Rafael B. G., Silva, Arnobio A., Rocha, Hugo A. O., Rebecchi, Ivanise M. M., Zucolotto, Silvana M., Fernandes-Pedrosa, Matheus F. Aqueous leaf extract of Jatropha gossypiifolia L. (Euphorbiaceae) inhibits enzymatic and biological actions of Bothrops jararaca snake venom. Plos one, 2014, p. e104952/1-e104952/14.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature