Botanical species · safety record

Jatropha multifida

The EFSA Compendium of Botanicals holds 22 constituent measurements, 3 adverse-effect records and 1 genotoxicity assay for Jatropha multifida. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Jatropha multifida L.

22Constituent measurements

4Safety records

10Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Stem / stalk	Solvent extraction	1.7 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Alkaloids	Seed	Solvent extraction	2.6 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Alkaloids	Leaves	Solvent extraction	2.9 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Alkaloids	Roots and other underground parts	Solvent extraction	1.7 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Anthracene derivatives	Leaves	—	—	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Coumarins	Stem / stalk	—	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Coumarins	Leaves	—	—	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Diterpene ketones	Stem / stalk	—	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Saponins	Roots and other underground parts	Solvent extraction	2.2 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Saponins	Leaves	Solvent extraction	3.2 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Saponins	Seed	Solvent extraction	2.4 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Saponins	Stem / stalk	Solvent extraction	2.7 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Tannins	Leaves	Solvent extraction	5.2 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Tannins	Stem / stalk	Solvent extraction	1.2 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Tannins	Seed	Solvent extraction	3.9 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Tannins	Roots and other underground parts	Solvent extraction	1.2 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Tannins	Leaves	—	—	Traditional analytical techniques (wet chemical tests)	Resolve DOI
3,4-dihydroxybenzoic acid	Unspecified	Solvent extraction	3.4 Microgram/millilitre	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Alkaloids	Roots and other underground parts	Solvent extraction	—	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Phorbol esters	Seed	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Saponins	Roots and other underground parts	Solvent extraction	—	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Tannins	Roots and other underground parts	Solvent extraction	—	Traditional analytical techniques (wet chemical tests)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Digestive	Fruit unspecified	—	Human (as organism)	Case report	Resolve DOI
Digestive	Liver	Seed	—	Dog (as animal)	Case report	No resolvable identifier
Digestive	Digestive	Fruit unspecified	—	—	Case report	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	bacterial gene mutation assay	Salmonella typhimurium (as organism)	With and without	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Das, Biswanath., Reddy, Kongara Ravinder., Ravikanth, Bommena., Raju, Tuniki Venugopal., Sridhar, Balasubramanian., Khan, Patan Usman., Rao, Janapala Venkateswara. Multifidone: A novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida . Bioorganic & medicinal chemistry letters, 2009, vol. 19, no. 1, p. 77-79. DOI
Dougnon, Tamegnon Victorien., Klotoe, Jean Robert., Segbo, Julien., Ategbo, Jean-Marc., Edorh, Aleodjrodo Patrick., Gbaguidi, Fernand., Hounkpatin, Armelle Sabine., Dandjesso, Carlos., Fah, Lauris., Fanou, Brice., Dramane, Karim., Loko, Frederic. Evaluation of the phytochemical and hemostatic potential of Jatropha multifida sap. AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, 2012, vol. 6, no. 26, p. 1943-1948. DOI
Butler, J. Toxicology case: Jatropha multifida toxicosis in a dog. Veterinary medicine, 2014, vol. 109, no. 6.
Nwokocha., Blessing, A., Agbagwa, I.O., Okoli, B.E. Comparative phytochemical screening of Jatropha L. Species in the Niger Delta. Research journal of phytochemistry, 2011, vol. 5, no. 2, p. 107-114. DOI
van den Bout-van den Beukel, Carolien J. P., Hamza, Omar J. M., Moshi, Mainen J., Matee, Mecky I. N., Mikx, Frans., Burger, David M., Koopmans, Peter P., Verweij, Paul E., Schoonen, Willem G. E. J., van der Ven, Andre J. A. M. Evaluation of cytotoxic, genotoxic and CYP450 enzymatic competition effects of tanzanian plant extracts traditionally used for treatment of fungal infections . Basic & clinical pharmacology & toxicology, 2008, vol. 102, no. 6, p. 515-526. DOI
Settharaksa, S., Pathompak, P., Saingam, W., Madaka, F., Chakree, K., Charoenchai, L. Development and validation of a RP-HPLC method for identification and estimation of gallic acid and protocatechuic acid in trigasornmas recipe. International journal of pharmaceutical, chemical and biological sciences, 2015, p. 388-393.
Falodun, Abiodun., Igbe, Ighodaro., Erharuyi, Osayemwenre., Agbanyim, Onyinye Jacinta. Chemical characterization, anti inflammatory and analgesic properties of Jatropha multifida root bark. Journal of applied sciences and environmental management, 2013, p. 357-362.
Koltin, D., Uziel, Y., Schneidermann, D., Kotzki, S., Wolach, B., Fainmesser, P. A case of Jatropha multifida poisoning resembling organophosphate intoxication. CLINICAL TOXICOLOGY, 2006, vol. 44, no. 3, p. 337-338. DOI
Lurie, Y., Fainmesser, P., Yosef, M., Bentur, Y. Remote identification of poisonous plants by cell-phone camera and online communication. Israel medical association journal, 2008, vol. 10, no. 11, p. 802-803.
Adolf, W., Opferkuch, H. J., Hecker, E. Irritant phorbol derivatives from Jatropha species. Phytochemistry (Elsevier), 1984, p. 129-132.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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