Botanical species · safety record

Juglans nigra

The EFSA Compendium of Botanicals holds 8 constituent measurements and 3 adverse-effect records for Juglans nigra. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Juglans nigra L.

8Constituent measurements

3Safety records

5Cited sources

268Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 268 licensed products naming Juglans nigra as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid

Source material stated

Aged bark
Bark
Brou de noix non mûr
Enveloppe (fruit)
Fruit
Fruit Hull
Green hulls
Hull

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Gallic acid	Wood	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Juglone	Leaves	Solvent extraction	≤ 2.9 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Juglone	Unspecified	—	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Juglone	Roots and other underground parts	Solvent extraction	≤ 8.82 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Juglone	Roots and other underground parts	Solvent extraction	≥ 7.21 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Juglone	Seed	Solvent extraction	≤ 9.42 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Juglone	Seed	Solvent extraction	≥ 4.41 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Juglone	Leaves	Solvent extraction	≥ 1.76 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Stomach	Seed	Fresh	Dog (as animal)	Case report	Resolve DOI
Neurotoxicity	Neurologic	Wood	Fresh	Dog (as animal)	Case report	Resolve DOI
Other toxicities	Cardiovascular / haematological	Wood	Solvent extraction	Horse (as animal)	Short-term toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Coleman AE., Merola V. Clinical signs associated with ingestion of black walnut tree (Juglans nigra)wood, nuts, and hulls in dogs: 93 cases (2001-2012).. Journal of the American Veterinary Medical Association, 2016, vol. 248, no. 2, p. 195-200. DOI
Lee, Kuo-Chuan., Campbell, Richard W. Nature and occurrence of juglone in Juglans nigra. Hortscience, 1969, p. 297-298.
Mapelli, S., Bertani, A. Involvement of phenolic compounds in walnut trees responses to soil flooding. Izvestiya vysshikh uchebnykh zavedenii, lesnoi zhurnal, 2015, p. 21-29.
EATON, SA., ALLEN, D., EADES, SC., SCHNEIDER, DA. DIGITAL STARLING FORCES AND HEMODYNAMICS DURING EARLY LAMINITIS INDUCED BY AN AQUEOUS EXTRACT OF BLACK-WALNUT (JUGLANS NIGRA) IN HORSES . American journal of veterinary research, 1995, vol. 56, no. 10, p. 1338-1344.
Bianco, MA., Handaji, A., Savolainen, H. Quantitative analysis of ellagic acid in hardwood samples. SCIENCE OF THE TOTAL ENVIRONMENT, 1998, vol. 222, no. 1-2, p. 123-126. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature