Botanical species · safety record

Juglans regia

The EFSA Compendium of Botanicals holds 8 constituent measurements and 1 genotoxicity assay for Juglans regia. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Juglans regia L.

8Constituent measurements

1Safety records

4Cited sources

151Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 151 licensed products naming Juglans regia as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh

Source material stated

Aged bark
Bark
Bud
Buds
Equal parts leaves and skin of the green fruit
Flower
Fresh green peel of the fruit
Fruit

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
1,8-cineole	Bark	Solvent extraction	1.6 Percent	GC-MS	Resolve DOI
Alpha-thujone	Bark	Solvent extraction	0.7 Percent	GC-MS	Resolve DOI
Camphor	Bark	Solvent extraction	16.6 Percent	GC-MS	Resolve DOI
Juglone	Leaves	Solvent extraction	≥ 5025 Microgram/gram	HPLC-DAD	Resolve DOI
Juglone	Bark	Solvent extraction	5 Percent	GC-MS	Resolve DOI
Juglone	Leaves	Solvent extraction	≤ 5145 Microgram/gram	HPLC-DAD	Resolve DOI
Chlorogenic acid	Seed	Solvent extraction	13.6 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Gallic acid	Seed	Solvent extraction	10.7 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Human (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Babula, Petr., Mikelova, Radka., Adam, Vojtech., Kizek, Rene., Havel, Ladislav., Sladky, Zdenek. Using of liquid chromatography coupled with diode array detector for determination of naphthoquinones in plants and for investigation of influence of pH of cultivation medium on content of plumbagin in Dionaea muscipula . Journal of chromatography b-analytical technologies in the biomedical and life sciences, 2006, vol. 842, no. 1, p. 28-35. DOI
Strelyaeva, A.V., Lezhava, D.I., Luferov, A.N., Kuznetsov, R.M., Bobkova, N.V., Lazareva, Yu.B., Kostikova, E.N. Study of quality medicinal plants bark walnuts and extract from it. Pharmacognosy journal, 2020, vol. 12, no. 2, p. 282-286. DOI
Lee, Jisoo., Kim, Yoo-Sun., Lee, JaeHwan., Heo, Seung Chul., Lee, Kook Lae., Choi, Sang-Woon., Kim, Yuri. Walnut phenolic extract and its bioactive compounds suppress colon cancer cell growth by regulating colon cancer stemness. Nutrients, 2016, vol. 8, no. 7, p. 439/1-439/14.
Arora, S., Brits, E., Kaur, S., Kaur, K., Sohi, RS., Kumar, S., Verschaeve, L. Evaluation or genotoxicity of medicinal plant extracts by the comet and VITOTOX (R) tests . Journal of environmental pathology toxicology and oncology, 2005, vol. 24, no. 3, p. 193-200. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature