Botanical species · safety record

Juniperus sabina

The EFSA Compendium of Botanicals holds 18 constituent measurements and 1 adverse-effect record for Juniperus sabina. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Juniperus sabina L.

18Constituent measurements

1Safety records

5Cited sources

1Licensed products (Canada)

Also recorded as

Sabina vulgaris Antoine
Juniperus sabina var. tamariscifolia Aiton

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1 licensed products naming Juniperus sabina as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Leafy twigs

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Deoxypodophyllotoxin	Leaves	Solvent extraction	≤ 721.2 Milligram/100 gram	LC-MS (quadrupole)	Resolve DOI
Deoxypodophyllotoxin	Leaves	Solvent extraction	≥ 209.3 Milligram/100 gram	LC-MS (quadrupole)	Resolve DOI
Podophyllotoxin	Leaves	Solvent extraction	≤ 349 Milligram/100 gram	LC-MS (quadrupole)	Resolve DOI
Podophyllotoxin	Leaves	Solvent extraction	≥ 45 Milligram/100 gram	LC-MS (quadrupole)	Resolve DOI
Alpha-cedrol	Leaves	Essential oil	≤ 15.9 Percent	GC-FID-MS	No resolvable identifier
Beta-thujone	Leaves	Essential oil	≤ 2.8 Percent	GC-FID-MS	No resolvable identifier
Beta-thujone	Leaves	Essential oil	≥ 0.1 Percent	GC-FID-MS	No resolvable identifier
Deoxypodophyllotoxin	Leaves	Solvent extraction	≤ 2 Milligram/gram	LC-MS	No resolvable identifier
Deoxypodophyllotoxin	Leaves	Solvent extraction	≥ 1.6 Milligram/gram	LC-MS	No resolvable identifier
Methyleugenol	Leaves	Essential oil	≤ 4.2 Percent	GC-FID-MS	No resolvable identifier
Methyleugenol	Leaves	Essential oil	≥ 1.1 Percent	GC-FID-MS	No resolvable identifier
Myrcene	Leaves	Essential oil	≤ 4.2 Percent	GC-FID-MS	No resolvable identifier
Myrcene	Leaves	Essential oil	≥ 3 Percent	GC-FID-MS	No resolvable identifier
Podophyllotoxin	Leaves	Solvent extraction	≤ 2.4 Milligram/gram	LC-MS	No resolvable identifier
Podophyllotoxin	Leaves	Solvent extraction	≥ 2.2 Milligram/gram	LC-MS	No resolvable identifier
Safrole	Leaves	Essential oil	≤ 3.2 Percent	GC-FID-MS	No resolvable identifier
Umbelliferone	Leaves	Solvent extraction	≤ 5.67 Milligram/100 gram	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Umbelliferone	Leaves	Solvent extraction	≥ 0.86 Milligram/100 gram	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Reproductive	Testes	Fruit unspecified	Powder	Rat (as animal)	Reproduction toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Xie Shuwu., Li Guoting., Zhong Ruihua., Zhou Jieyun., Guo Xiangjie., Li Zhao., Ma Aying., Zhu Yan., Qu Lijuan., Chen Ping., . Podophyllotoxin Extracted from Juniperus sabina Fruit Inhibits Rat Sperm Maturation and Fertility by Promoting Epididymal Epithelial Cell Apoptosis. Evidence-based complementary and alternative medicine : ecam, 2017, vol. 2017, p. 6958982.
Adams, Robert P., Nguyen, Sanko., Liu, Jianquan. Geographic variation in the leaf essential oils of Juniperus sabina L. and J-sablina var. arenaria (E.H. Wilson) Farjon . Journal of essential oil research, 2006, vol. 18, no. 5, p. 497-502.
Renouard, Sullivan., Lopez, Tatiana., Hendrawati, Oktavia., Dupre, Patricia., Doussot, Joel., Falguieres, Annie., Ferroud, Clotilde., Hagege, Daniel., Lamblin, Frederic., Laine, Eric., . Podophyllotoxin and Deoxypodophyllotoxin in Juniperus bermudiana and 12 Other Juniperus Species: Optimization of Extraction, Method Validation, and Quantification. Journal of agricultural and food chemistry, 2011, vol. 59, no. 15, p. 8101-8107.
Och, Marek., Och, Anna., Ciesla, Lukasz., Kocki, Janusz., Bogucka-Kocka, Anna. Screening various Juniperus species for the occurrence of umbelliferone by means of bivariate multiple development thin-layer chromatography. Journal of planar chromatography--modern tlc, 2013, vol. 26, no. 5, p. 421-426.
Och, M., Och, A., Ciesla, L., Kubrak, T., Pecio, L., Stochmal, A., Kocki, J., Bogucka-Kocka, A. Study of cytotoxic activity, podophyllotoxin, and deoxypodophyllotoxin content in selected Juniperus species cultivated in Poland. Pharmaceutical biology, 2015, vol. 53, no. 6, p. 831-837. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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