Botanical species · safety record

Juniperus virginiana

The EFSA Compendium of Botanicals holds 28 constituent measurements for Juniperus virginiana. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Juniperus virginiana L.

28Constituent measurements

0Safety records

8Cited sources

10Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 10 licensed products naming Juniperus virginiana as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Twigs

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
6-methoxypodophyllotoxin	Leaves	Solvent extraction	0.06 Percent	LC-HR-MS	Resolve DOI
Deoxypodophyllotoxin	Leaves	Solvent extraction	≥ 2.7 Milligram/gram	HPLC-MS/MS	Resolve DOI
Deoxypodophyllotoxin	Leaves	Solvent extraction	0.22 Percent	LC-HR-MS	Resolve DOI
Deoxypodophyllotoxin	Leaves	Solvent extraction	≤ 390 Milligram/100 gram	LC-MS (quadrupole)	Resolve DOI
Deoxypodophyllotoxin	Leaves	Solvent extraction	≥ 91.2 Milligram/100 gram	LC-MS (quadrupole)	Resolve DOI
Deoxypodophyllotoxin	Leaves	Solvent extraction	≤ 4.5 Milligram/gram	HPLC-MS/MS	Resolve DOI
Lignans, total	Leaves	Solvent extraction	3.24 Percent	LC-HR-MS	Resolve DOI
Matairesinol	Leaves	Solvent extraction	0.08 Percent	LC-HR-MS	Resolve DOI
Myrcene	Leaves	Essential oil	≥ 0.27 Percent	GC-MS	Resolve DOI
Myrcene	Leaves	Essential oil	≤ 4.04 Percent	GC-MS	Resolve DOI
Podophyllotoxin	Leaves	Solvent extraction	≥ 0.178 Percent	HPLC-DAD	Resolve DOI
Podophyllotoxin	Leaves	Solvent extraction	2.09 Percent	LC-HR-MS	Resolve DOI
Podophyllotoxin	Leaves	Solvent extraction	≥ 4.3 Milligram/100 gram	LC-MS (quadrupole)	Resolve DOI
Podophyllotoxin	Leaves	Solvent extraction	≥ 16.5 Milligram/gram	HPLC-MS/MS	Resolve DOI
Podophyllotoxin	Leaves	Solvent extraction	≤ 19.1 Milligram/gram	HPLC-MS/MS	Resolve DOI
Podophyllotoxin	Leaves	Solvent extraction	≤ 384.5 Milligram/100 gram	LC-MS (quadrupole)	Resolve DOI
Podophyllotoxin	Leaves	Solvent extraction	≤ 0.342 Percent	HPLC-DAD	Resolve DOI
Safrole	Leaves	Essential oil	≤ 48.24 Percent	GC-MS	Resolve DOI
Safrole	Leaves	Essential oil	≥ 27.49 Percent	GC-MS	Resolve DOI
Secoisolariciresinol glucoside	Leaves	Solvent extraction	0.03 Percent	LC-HR-MS	Resolve DOI
Yatein	Leaves	Solvent extraction	0.76 Percent	LC-HR-MS	Resolve DOI
Myrcene	Leaves	Solvent extraction	2.8 Percent	GC-MS	No resolvable identifier
Podophyllotoxin	Leaves	Solvent extraction	≤ 1.56 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Podophyllotoxin	Leaves	Solvent extraction	≥ 0.6 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Podophyllotoxin	Leaves	Solvent extraction	≤ 1.56 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Podophyllotoxin	Leaves	Solvent extraction	≥ 1.06 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Umbelliferone	Leaves	Solvent extraction	≤ 5.38 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Umbelliferone	Leaves	Solvent extraction	≥ 0.05 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Doussot, J., Mathieu, V., Colas, C., Molini�, R., Corbin, C., Montguillon, J., Moreno Y Banuls, L., Renouard, S., Lamblin, F., Dupr�, P., Maunit, B., Kiss, R., Hano, C., Lain�, E. Investigation of the Lignan Content in Extracts from Linum, Callitris and Juniperus Species in Relation to Their In Vitro Antiproliferative Activities. Planta medica, 2017, vol. 83, no. 6, p. 574-581. DOI
Renouard, Sullivan., Lopez, Tatiana., Hendrawati, Oktavia., Dupre, Patricia., Doussot, Joel., Falguieres, Annie., Ferroud, Clotilde., Hagege, Daniel., Lamblin, Frederic., Laine, Eric., Hano, Christophe. Podophyllotoxin and Deoxypodophyllotoxin in Juniperus bermudiana and 12 Other Juniperus Species: Optimization of Extraction, Method Validation, and Quantification . Journal of agricultural and food chemistry, 2011, vol. 59, no. 15, p. 8101-8107. DOI
Cantrell, Charles L., Zheljazkov, Valcho D., Osbrink, Weste L. A., Castro, Amaya., Maddox, Victor., Craker, Lyle E., Astatkie, Tess. Podophyllotoxin and essential oil profile of Juniperus and related species . Industrial crops and products, 2013, vol. 43, p. 668-676. DOI
Och, M., Och, A., Ciesla, L., Kubrak, T., Pecio, L., Stochmal, A., Kocki, J., Bogucka-Kocka, A. Study of cytotoxic activity, podophyllotoxin, and deoxypodophyllotoxin content in selected Juniperus species cultivated in Poland. Pharmaceutical biology, 2015, vol. 53, no. 6, p. 831-837. DOI
Maqbool, M., Cushman, KE., Gerard, PD., Bedir, E., Lata, H., Moraes, RM., Craker, LE., Simon, JE., Jatisatienr, A., Lewinsohn, E. Podophyllotoxin content in leaves of eastern red cedar (Juniperus virginiana) . Future for medicinal and aromatic plants, 2004, no. 629, p. 87-92.
Cushman, KE., Maqbool, M., Gerard, PD., Bedir, E., Lata, H., Moraes, RM. Variation of podophyllotoxin in leaves of eastern red cedar (Juniperus virginiana) . Planta medica, 2003, vol. 69, no. 5, p. 477-478.
Och, Marek., Och, Anna., Ciesla, Lukasz., Kocki, Janusz., Bogucka-Kocka, Anna. Screening various Juniperus species for the occurrence of umbelliferone by means of bivariate multiple development thin-layer chromatography. Journal of planar chromatography--modern tlc, 2013, vol. 26, no. 5, p. 421-426.
Jo, GG., Kim, JH. Infraspecific variability of Juniperus L. (Cupressaceae) based on monoterpenoid compositions . Journal of plant biology, 2005, vol. 48, no. 2, p. 155-158.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature