Botanical species · safety record

Justicia adhatoda

The EFSA Compendium of Botanicals holds 18 constituent measurements and 5 adverse-effect records for Justicia adhatoda. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Justicia adhatoda L.

18Constituent measurements

5Safety records

8Cited sources

65Licensed products (Canada)

Also recorded as

Adhatoda vasica Nees

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 65 licensed products naming Justicia adhatoda as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Fresh leaf
Fruit
Justicia adhatoda - leaf
Leaf
Leaves
Root
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	—	Unspecified	Resolve DOI
Alkaloids	Live plants	Solvent extraction	1.13 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Cardiac glycosides	Live plants	Solvent extraction	—	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Peganine	Live plants	—	≥ 0.0541 Percent	Unspecified	Resolve DOI
Peganine	Live plants	—	≤ 1.105 Percent	Unspecified	Resolve DOI
Peganine	Leaves	Solvent extraction	—	Unspecified	Resolve DOI
Phlobotannins	Live plants	Solvent extraction	—	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Quinazoline alkaloids	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Quinazoline alkaloids	Roots and other underground parts	—	—	Unspecified	Resolve DOI
Quinazoline alkaloids	Leaves	—	—	Unspecified	Resolve DOI
Saponins	Live plants	Solvent extraction	2.09 Percent	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Neoandrographolide	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Peganine	Leaves	Solvent extraction	0.85 Percent	HPLC-DAD	No resolvable identifier
Peganine	Leaves	Solvent extraction	≤ 32080 Microgram/gram	UHPLC-MS-MS	No resolvable identifier
Peganine	Leaves	Solvent extraction	≥ 932.5 Microgram/gram	UHPLC-MS-MS	No resolvable identifier
Vasicinone	Leaves	Solvent extraction	≥ 331.4 Microgram/gram	UHPLC-MS-MS	No resolvable identifier
Vasicinone	Leaves	Solvent extraction	≤ 34450 Microgram/gram	UHPLC-MS-MS	No resolvable identifier
Vasicinone	Leaves	Solvent extraction	0.027 Percent	HPLC-DAD	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Reproductive	Urogenital	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	—	Live plants	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	—	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier
Reproductive	—	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier
Reproductive	—	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Paulraj, M. Gabriel., Shanmugam, N., Ignacimuthu, S. Antifeedant activity and toxicity of two alkaloids from Adhatoda vasica Nees leaves against diamondback moth Plutella xylostella (Linn.) (Lepidoptera: Plutellidae) larvae . Archives of phytopathology and plant protection, 2014, vol. 47, no. 15, p. 1832-1840. DOI
Burgos, R., Forcelledo, M., Wagner, H., Muller, A., Hancke, J., Wikman, G., Croxatto, H. Non-abortive effect of Adhatoda vasica spissum leaf extract by oral administration in rats . Phytomedicine, 1997, vol. 4, no. 2, p. 145-149.
NATH, D., SETHI, N., SINGH, RK., JAIN, AK. COMMONLY USED INDIAN ABORTIFACIENT PLANTS WITH SPECIAL REFERENCE TO THEIR TERATOLOGIC EFFECTS IN RATS. JOURNAL OF ETHNOPHARMACOLOGY, 1992, vol. 36, no. 2, p. 147-154. DOI
Claeson, UP., Malmfors, T., Wikman, G., Bruhn, JG. Adhatoda vasica: a critical review of ethnopharmacological and toxicological data . Journal of ethnopharmacology, 2000, vol. 72, no. 1-2, p. 1-20. DOI
Khan, Amir Muhammad., Qureshi, Rizwana Aleem., Ullah, Faizan., Gilani, Syed Aneel., Nosheen, Asia., Sahreen, Sumaira., Laghari, Muhammad Khan., Laghari, Muhammad Yousif., Shafiq-Ur-Rehman., Hussain, Ishtiaq., Murad, Waheed. Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings. JOURNAL OF MEDICINAL PLANTS RESEARCH, 2011, vol. 5, no. 25, p. 6017-6023. DOI
Al-Amin, Md., Islam, Md. Monirul., Siddiqi, M. Mahboob Ali., Akter, Shakila., Ahmed, Shamim., Haque, Mohammad Majedul., Sultana, Nasim., Chowdhury, A. M. Sarwaruddin. Neoandrographolide isolated from leaves of Adhatoda vasica Nees. Dhaka university journal of science, 2012, vol. 60, no. 1, p. 1-3.
Singh Awantika., Kumar Sunil., Bajpai Vikas., Kumar Brijesh., Singh Awantika., Bajpai Vikas., Kumar Brijesh. Simultaneous determination of pyrroquinazoline alkaloids and flavonoids in Adhatoda beddomei and Adhatoda vasica and their marketed herbal formulations using ultra-high-performance liquid chromatography coupled with triple quadrupole linear ion trap mass spectrometry. Biomedical chromatography : bmc, 2017, p. 31(3).
Gao, Hong., Huang, Yi-Na., Gao, Bo., Li, Peng., Inagaki, Chika., Kawabata, Jun. Inhibitory effect on alpha-glucosidase by Adhatoda vasica Nees. Food chemistry, 2008, vol. 108, no. 3, p. 965-972. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature