Botanical species · safety record

Lactuca virosa

The EFSA Compendium of Botanicals holds 12 constituent measurements and 1 adverse-effect record for Lactuca virosa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Lactuca virosa L.

12Constituent measurements

1Safety records

4Cited sources

51Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 51 licensed products naming Lactuca virosa as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Fresh

Source material stated

Fresh above ground parts
Herb
Leaf
Leaf/Leaves
Leaves
Plante entière
Sève
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Lactucin	Live plants	Solvent extraction	256.9 Microgram/gram	HPLC-UV	Resolve DOI
Lactucopicrin	Live plants	Solvent extraction	1732.7 Microgram/gram	HPLC-UV	Resolve DOI
Sesquiterpene lactones	Leaves	Solvent extraction	≤ 0.25 Milligram/gram	HPLC-DAD	Resolve DOI
Sesquiterpene lactones	Leaves	Solvent extraction	≥ 0.025 Milligram/gram	HPLC-DAD	Resolve DOI
Sesquiterpene lactones	Roots and other underground parts	Solvent extraction	≥ 0.025 Milligram/gram	HPLC-DAD	Resolve DOI
Sesquiterpene lactones	Roots and other underground parts	Solvent extraction	≤ 0.25 Milligram/gram	HPLC-DAD	Resolve DOI
Sesquiterpene lactones	Live plants	Solvent extraction	173.5 Microgram/gram	HPLC-UV	Resolve DOI
Sesquiterpene lactones	Leaves	Solvent extraction	< 0.025 Milligram/gram	HPLC-DAD	Resolve DOI
Sesquiterpene lactones	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Sesquiterpene lactones	Roots and other underground parts	Solvent extraction	< 0.025 Milligram/gram	HPLC-DAD	Resolve DOI
Sesquiterpene lactones	Leaves	Solvent extraction	≤ 2.5 Milligram/gram	HPLC-DAD	Resolve DOI
Sesquiterpene lactones	Leaves	Solvent extraction	≥ 0.25 Milligram/gram	HPLC-DAD	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	Neurologic: central nervous system	Aerial part of plants	Raw, no heat treatment	Human (as organism)	Case report	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Michalska, Klaudia., Stojakowska, Anna., Malarz, Janusz., Dolezalova, Ivana., Lebeda, Ales., Kisiel, Wanda. Systematic implications of sesquiterpene lactones in Lactuca species. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2009, vol. 37, no. 3, p. 174-179. DOI
TAMAKI, H., ROBINSON, RW., ANDERSON, JL., STOEWSAND, GS. SESQUITERPENE LACTONES IN VIRUS-RESISTANT LETTUCE. Journal of agricultural and food chemistry, 1995, vol. 43, no. 1, p. 6-8. DOI
Kisiel, W., Barszcz, B. Minor sesquiterpene lactones from Lactuca virosa. Phytochemistry, 1997, vol. 46, no. 7, p. 1241-1243. DOI
Besharat, Sima., Besharat, Mahsa., Jabbari, Ali. Wild lettuce (Lactuca virosa) toxicity.. Bmj case reports, 2009, vol. 2009. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature