Botanical species · safety record

Lagenaria siceraria

The EFSA Compendium of Botanicals holds 10 constituent measurements and 8 adverse-effect records for Lagenaria siceraria. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Lagenaria siceraria (Molina) Standl.

10Constituent measurements

8Safety records

8Cited sources

2Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 2 licensed products naming Lagenaria siceraria as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Extract Type TBA

Source material stated

Fruit
Fruit(s)
Shell

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Seed	—	—	Phytochemical screening	Resolve DOI
Cucurbitacin b	Aerial part of plants	Solvent extraction	0.017 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Cucurbitacin b	Fruit unspecified	Solvent extraction	0.062 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Gallic acid	Fruit unspecified	Drying (dehydration)	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Periplogenin	Fruit unspecified	Drying (dehydration)	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Saponins	Seed	—	—	Phytochemical screening	Resolve DOI
Hydrocyanic acid	Seed	Solvent extraction	12 Milligram/100 gram	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Oxalates	Seed	Solvent extraction	8 Percent	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Phytic acid	Seed	Solvent extraction	4 Milligram/gram	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Saponins	Seed	Solvent extraction	4 Percent	Traditional analytical techniques (wet chemical tests)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Fruit unspecified	Solvent extraction	Human (as organism)	Acute toxicity	Resolve DOI
Digestive	Digestive	Fruit unspecified	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive	Fruit unspecified	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive	Fruit unspecified	Thermal treatment (heating for preservation)	Human (as organism)	Case report	Resolve DOI
Systemic	Digestive	Fruit unspecified	Drying (dehydration)	Goat (as animal)	Short-term toxicity	Resolve DOI
Systemic	Digestive	Fruit unspecified	Fresh	Goat (as animal)	Short-term toxicity	Resolve DOI
Systemic	Digestive	Leaves	Drying (dehydration)	Goat (as animal)	Short-term toxicity	Resolve DOI
Systemic	Digestive	Seed	Drying (dehydration)	Goat (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Verma A., Jaiswal S. Bottle gourd (Lagenaria siceraria) juice poisoning.. World journal of emergency medicine, 2015, vol. 6, no. 4, p. 308-9. DOI
Barri, M.E.S., Onsa, T.O., Elawad, A.A., Elsayed, N.Y., Wasfi, I.A., Abdul Bari, E.M., Adam, S.E.I. Toxicity of five Sudanese plants to young ruminants. Journal of Comparative Pathology, 1983, vol. 93, no. 4, p. 559-575. DOI
Sulaiman, Shaida Fariza., Ooi, Kheng Leong., Supriatno. Antioxidant and alpha-glucosidase inhibitory activities of cucurbit fruit vegetables and identification of active and major constituents from phenolic-rich extracts of Lagenaria siceraria and Sechium edule.. Journal of agricultural and food chemistry, 2013, vol. 61, no. 42, p. 10080-90. DOI
Ojiako, O. A., Igwe, C. U. Nutritional and anti-nutritional compositions of Cleome rutidosperma, Lagenaria siceraria, and Cucurbita maxima seeds from Nigeria . Journal of medicinal food, 2007, vol. 10, no. 4, p. 735-738. DOI
Kumbhalkar, Bhagyashri., Tamhankar, Shubhada., Upadhye, Anuradha. Development of a High-Performance Thin-Layer Chromatographic Method for Quantification of Cucurbitacin B in Bottle Gourd (Lagenaria siceraria) for Quality Control . Jpc-journal of planar chromatography-modern tlc, 2015, vol. 28, no. 4, p. 294-299. DOI
Badifu, G. I. O. Effect of Processing on Proximate Composition, Antinutritional and Toxic Contents of Kernels from Cucurbitaceae Species Grown in Nigeria. Journal of food composition and analysis, 2001, p. 153-161.
Panda, S., Kar, A. Periplogenin, Isolated from Lagenaria siceraria, Ameliorates L-T-4-induced Hyperthyroidism and Associated Cardiovascular Problems. HORMONE AND METABOLIC RESEARCH, 2011, vol. 43, no. 3, p. 188-193. DOI
Ho, Cynthia H., Ho, Michael G., Ho, Shin-Pin., Ho, Helen H. BITTER BOTTLE GOURD (LAGENARIA SICERARIA) TOXICITY. Journal of emergency medicine, 2014, vol. 46, no. 6, p. 772-775. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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