Botanical species · safety record

Larrea divaricata

The EFSA Compendium of Botanicals holds 3 constituent measurements and 4 adverse-effect records for Larrea divaricata. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Larrea divaricata Cav.

3Constituent measurements

4Safety records

4Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Lignans	Aerial part of plants	Solvent extraction	—	Chromatographic tests	Resolve DOI
Nordihydroguaiaretic acid	Aerial part of plants	Solvent extraction	0.1 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Nordihydroguaiaretic acid	Leaves	Resin	15.6 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Nephrotoxicity	Urogenital: kidneys	Unspecified	—	Rat (as animal)	Chronic/long term toxicity	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Unspecified	—	Rat (as animal)	Chronic/long term toxicity	Resolve DOI
Other toxicities	Cardiovascular / haematological: lymph nodes	Unspecified	—	Rat (as animal)	Chronic/long term toxicity	Resolve DOI
Other toxicities	Cardiovascular / haematological: lymph nodes	Unspecified	—	Rat (as animal)	Chronic/long term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

GRICE, HC., BECKING, G., GOODMAN, T. TOXIC PROPERTIES OF NORDIHYDROGUAIARETIC ACID. Food and cosmetics toxicology, 1968, vol. 6, no. 2, p. 155-&. DOI
Rivero-Cruz, I., Acevedo, L., Guerrero, JA., Martinez, S., Bye, R., Pereda-Miranda, R., Franzblau, S., Timmermann, BN., Mata, R. Antimycobacterial agents from selected Mexican medicinal plants. Journal of pharmacy and pharmacology, 2005, vol. 57, no. 9, p. 1117-1126. DOI
Bongiovanni, Guillermina., Cantero, Juan., Eynard, Aldo., Goleniowski, Marta. Organic extracts of Larrea divaricata Cav. induced apoptosis on tumoral MCF7 cells with an higher cytotoxicity than nordihydroguaiaretic acid or paclitaxel. . Journal of experimental therapeutics & oncology, 2008, vol. 7, no. 1, p. 1-7.
Rios, J. M., Mangione, A. M., Gianello, J. C. Effects of natural phenolic compounds from a desert dominant shrub Larrea divaricata Cav. on toxicity and survival in mice . Revista chilena de historia natural, 2008, vol. 81, no. 2, p. 293-302.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature