Botanical species · safety record

Larrea tridentata

The EFSA Compendium of Botanicals holds 8 constituent measurements and 2 adverse-effect records for Larrea tridentata. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Larrea tridentata (Sessé & Moc. ex DC.) Coville

8Constituent measurements

2Safety records

3Cited sources

2Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 2 licensed products naming Larrea tridentata as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Herb

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
(-)-guaiaretic acid	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Enterolactone	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Lignans	Leaves	Solvent extraction	—	LC-MS	No resolvable identifier
Lignans	Leaves	Solvent extraction	—	Chromatographic tests	No resolvable identifier
Matairesinol	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Nordihydroguaiaretic acid	Leaves	Solvent extraction	≤ 10 Percent	LC-MS	No resolvable identifier
Nordihydroguaiaretic acid	Leaves	Solvent extraction	≥ 5 Percent	LC-MS	No resolvable identifier
Secoisolarisiresinol	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Aerial part of plants	—	Human (as organism)	Case report	No resolvable identifier
Hepatotoxicity	Liver	Aerial part of plants	—	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

OBERMEYER, WR., MUSSER, SM., BETZ, JM., CASEY, RE., POHLAND, AE., PAGE, SW. CHEMICAL STUDIES OF PHYTOESTROGENS AND RELATED-COMPOUNDS IN DIETARY-SUPPLEMENTS - FLAX AND CHAPARRAL . Proceedings of the society for experimental biology and medicine, 1995, vol. 208, no. 1, p. 6-12.
Potential Mechanism of Action of 3'-Demethoxy-6-O-Demethylisoguaiacin on Methicillin-resistant Staphylococcus aureus . European nucleotide archive, 2015.
Ravichandiran, V., Satish, P.V. A review on hepatotoxicity of phytomedicines. International journal of pharmacognosy and phytochemical research, 2013, vol. 5, no. 3, p. 186-191.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature