Botanical species · safety record

Lawsonia inermis

The EFSA Compendium of Botanicals holds 8 constituent measurements, 4 adverse-effect records and 3 genotoxicity assays for Lawsonia inermis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Lawsonia inermis L.

8Constituent measurements

7Safety records

9Cited sources

0Licensed products (Canada)

Also recorded as

Lawsonia alba Lam.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Coumarins	Flower	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Lawsone	Leaves	Solvent extraction	≤ 0.608 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Lawsone	Leaves	Solvent extraction	≥ 0.004 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Naphthoquinones	Flower	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
P-coumaric acid	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Umbelliferone	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Alkaloids	Leaves	Solvent extraction	0.7 Percent	Phytochemical screening	No resolvable identifier
Saponins	Leaves	Solvent extraction	0.65 Percent	Phytochemical screening	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Systemic	Urogenital: kidneys	Leaves	Raw, no heat treatment	Human (as organism)	Case report	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Leaves	—	Human (as organism)	Case report	No resolvable identifier
Systemic	Cardiovascular / haematological	Leaves	Solvent extraction	Human (as organism)	Case report	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	micronucleus assay	House mouse (as animal)	Not applicable	Resolve DOI
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	—	Resolve DOI
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kirkland, D., Marzin, D. An assessment of the genotoxicity of 2-hydroxy-1,4-naphthoquinone, the natural dye ingredient of Henna . Mutation research-genetic toxicology and environmental mutagenesis, 2003, vol. 537, no. 2, p. 183-199. DOI
Kumar, M., Kumar, S., Kaur, S. Identification of polyphenols in leaf extracts of Lawsonia inermis L. with antioxidant, antigenotoxic and antiproliferative potential. International journal of green pharmacy, 2014, vol. 8, no. 1, p. 23-36. DOI
Ei-Shaer, Nagwa S., Badr, Jihan M., Aboul-Ela, Maha A., Gohar, Yousry M. Determination of lawsone in henna powders by high performance thin layer chromatography . Journal of separation science, 2007, vol. 30, no. 18, p. 3311-3315. DOI
Rund, Deborah., Schaap, Tova., Da'as, Nael., Yehuda, Dina Ben., Kalish, Joseph. Plasma exchange as treatment for lawsone (henna) intoxication. Journal of clinical apheresis, 2007, vol. 22, no. 4, p. 243-245. DOI
Mahmoud, I., Alkofahi, A., Abdelaziz, A. Mutagenic and toxic activities of several spices and some jordanian medicinal plants. Pharmaceutical biology, 1992, vol. 30, no. 2, p. 81-85. DOI
Bello, S.O., Bashar, I., Muhammad, B.Y., Onyeyili, P. Acute toxicity and uterotonic activity of aqueous extract of Lawsonia inermis (Lythraceae). Research journal of pharmaceutical, biological and chemical sciences, 2010, vol. 1, no. 3, p. 790-798.
Li, Qian., Gao, Wenqin., Cao, Jiaqing., Bi, Xiuli., Chen, Gang., Zhang, Xiaoshu., Xia, Xichun., Zhao, Yuqing. New cytotoxic compounds from flowers of Lawsonia inermis L.. Fitoterapia, 2014, vol. 94, p. 148-154. DOI
Qurashi, Hala E A., Qumqumji, Abbas A A., Zacharia, Yasir. Acute renal failure and intravascular hemolysis following henna ingestion. . Saudi journal of kidney diseases and transplantation : an official publication of the saudi center for organ transplantation, saudi arabia, 2013, vol. 24, no. 3, p. 553-6.
Perinet, I., Lioson, E., Tichadou, L., Glaizal, M., de Haro, L. Hemolytic anemia after voluntary ingestion of henna (Lawsonia inermis) decoction by a young girl with G6PD deficiency . . Medecine tropicale : revue du corps de sante colonial, 2011, vol. 71, no. 3, p. 292-4.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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