Botanical species · safety record

Leonotis leonurus

The EFSA Compendium of Botanicals holds 11 constituent measurements and 11 adverse-effect records for Leonotis leonurus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Leonotis leonurus (L.) R.Br.

11Constituent measurements

11Safety records

11Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Epoxides	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Labdane diterpenes	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Labdane diterpenes	Unspecified	Solvent extraction	—	Unspecified	Resolve DOI
Labdane diterpenes	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Saponins	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Stachydrine	Aerial part of plants	Solvent extraction	13.45 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Tannins	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Diterpene lactones	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Diterpene lactones	Unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Labdane diterpenes	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hemopoietic	Cardiovascular / haematological	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Hemopoietic	Cardiovascular / haematological	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Hepatotoxicity	Liver	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Hepatotoxicity	Liver	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Hepatotoxicity	Liver	Roots and other underground parts	Solvent extraction	Rat (as animal)	Subchronic	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Pulmonary and cardiac	Neurologic	Roots and other underground parts	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Pulmonary and cardiac	Lung	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Pulmonary and cardiac	Neurologic	Roots and other underground parts	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

He, Fang., Lindqvist, Charlotte., Harding, Wayne W. Leonurenones A-C: Labdane diterpenes from Leonotis leonurus. Phytochemistry, 2012, vol. 83, p. 168-172. DOI
Bienvenu, E., Amabeoku, GJ., Eagles, PK., Scott, G., Springfield, EP. Anticonvulsant activity of aqueous extract of Leonotis leonurus. Phytomedicine, 2002, vol. 9, no. 3, p. 217-223. DOI
Mnonopi, N., Levendal, R-A., Mzilikazi, N., Frost, C. L. Marrubiin, a constituent of Leonotis leonurus, alleviates diabetic symptoms . Phytomedicine, 2012, vol. 19, no. 6, p. 488-493. DOI
McKenzie, J. M., Green, I. R., Mugabo, P. Leonurun, a novel labdane diterpenoid from Leonotis leonurus. South african journal of chemistry-suid-afrikaanse tydskrif vir chemie, 2006, vol. 59, p. 114-116.
Kuchta, K., Volk, R. B., Rauwald, H. W. Stachydrine in Leonurus cardiaca, Leonurus japonicus, Leonotis leonurus: detection and quantification by instrumental HPTLC and H-1-qNMR analyses . Pharmazie, 2013, vol. 68, no. 7, p. 534-540. DOI
Maphosa, V., Masika, P. J., Adedapo, A. A. Safety evaluation of the aqueous extract of Leonotis leonurus shoots in rats . Human & experimental toxicology, 2008, vol. 27, no. 11, p. 837-843. DOI
Oyedemi, S. O., Yakubu, M. T., Afolayan, A. J. Effect of aqueous extract of Leonotis leonurus (L.) R. Br. leaves in male Wistar rats . Human & experimental toxicology, 2010, vol. 29, no. 5, p. 377-384. DOI
Wu, Hankui., Li, Jun., Fronczek, Frank R., Ferreira, Daneel., Burandt, Charles L., Jr., Setola, Vincent., Roth, Bryan L., Zjawiony, Jordan K. Labdane Diterpenoids from Leonotis leonurus. Phytochemistry, 2013, vol. 91, p. 229-235. DOI
Obikeze, Kene C., McKenzie, Jean M., Green, Ivan R., Mugabo, Pierre. Characterization and Cardiovascular Effects of (13S)-9 alpha, 13 alpha-epoxylabda-6 beta(19), 15(14)diol Dilactone, a Diterpenoid Isolated from Leonotis leonurus . South african journal of chemistry-suid-afrikaanse tydskrif vir chemie, 2008, vol. 61, p. 119-122.
Laonigro, Guglielmo., Lanzetta, Rosa., Parrilli, Michelangelo., Adinolfi, Matteo., Mangoni, Lorenzo. The configuration of the diterpene spiro ethers from Marrubium vulgare and from Leonotis leonurus. Gazzetta chimica italiana, 1979, p. 145-150.
Narukawa, Yuji., Komori, Miyuki., Niimura, Akiko., Noguchi, Hitomi., Kiuchi, Fumiyuki. Two new diterpenoids from Leonotis leonurus R. Br.. Journal of natural medicines, 2015, vol. 69, no. 1, p. 130-134. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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