Botanical species · safety record

Leonurus cardiaca

The EFSA Compendium of Botanicals holds 16 constituent measurements for Leonurus cardiaca. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Leonurus cardiaca L.

16Constituent measurements

0Safety records

7Cited sources

117Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 117 licensed products naming Leonurus cardiaca as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Fresh

Source material stated

Aerial parts
Aerial parts of the plant
Flower
Flowering grass
Flowers and leaves
Fresh above ground parts
Fresh aerial part collected at flowering time
Fresh aerial parts collected at flowering time

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Labdane diterpenes	Stem / stalk	Solvent extraction	≤ 0.6 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Labdane diterpenes	Stem / stalk	Solvent extraction	≥ 0.4 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Labdane diterpenes	Roots and other underground parts	Solvent extraction	≤ 0.05 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Labdane diterpenes	Flower	Solvent extraction	≤ 3.9 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Labdane diterpenes	Flower	Solvent extraction	≥ 2.4 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Labdane diterpenes	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Labdane diterpenes	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Labdane diterpenes	Roots and other underground parts	Solvent extraction	≥ 0.01 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Labdane diterpenes	Leaves	Solvent extraction	≤ 3.4 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Labdane diterpenes	Leaves	Solvent extraction	≥ 1.8 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Stachydrine	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Stachydrine	Aerial part of plants	Solvent extraction	1.212 Percent	HPLC-DAD	Resolve DOI
Stachydrine	Aerial part of plants	Solvent extraction	≤ 1.55 Percent	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Stachydrine	Aerial part of plants	Solvent extraction	≥ 0.12 Percent	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Dehydro-1,8-cineole	Aerial part of plants	Essential oil	8.9 Percent	GC-MS	No resolvable identifier
Labdane diterpenes	Shoot	—	—	Unspecified	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Morteza-Semnani, Katayoun., Saeedi, Majid., Akbarzadeh, Mohammad. The essential oil composition of Leonurus cardiaca L.. Journal of essential oil research, 2008, vol. 20, no. 2, p. 107-109.
Knoss, W., Zapp, J. Accumulation of furanic labdane diterpenes in Marrubium vulgare and Leonurus cardiaca . Planta medica, 1998, vol. 64, no. 4, p. 357-361. DOI
Knoess, Werner. Furanic labdane diterpenes in differentiated and undifferentiated cultures of Marrubium vulgare and Leonurus cardiaca . Plant physiology and biochemistry (montrouge), 1994, vol. 32, no. 6, p. 785-789.
Rauwald, Hans Wilhelm., Savtschenko, Alex., Merten, Alexander., Rusch, Christian., Appel, Kurt., Kuchta, Kenny. GABA(A) Receptor Binding Assays of Standardized Leonurus cardiaca and Leonurus japonicus Extracts as Well as Their Isolated Constituents . Planta medica, 2015, vol. 81, no. 12-13, p. 1103-1110. DOI
Papanov, Georgi Y., Malakov, Peter Y., Rodriguez, Benjamin., De La Torre, Maria C. A prefuranic labdane diterpene from Leonurus cardiaca. Phytochemistry (oxford), 1998, vol. 47, no. 6, p. 1149-1151. DOI
Ritter, Malte., Melichar, Kerstin., Strahler, Sabine., Kuchta, Kenny., Schulte, Jan., Sartiani, Laura., Cerbai, Elisabetta., Mugelli, Alessandro., Mohr, Friedrich-Wilhelm., Rauwald, Hans Wilhelm., Dhein, Stefan. Cardiac and Electrophysiological Effects of Primary and Refined Extracts from Leonurus cardiaca L. (Ph.Eur.) . Planta medica, 2010, vol. 76, no. 6, p. 572-582. DOI
Kuchta, Kenny., Ortwein, Jutta., Hennig, Lothar., Wilhelm-Rauwald, Hans. H-1-qNMR for direct quantification of stachydrine in Leonurus japonicus and L. cardiaca . Fitoterapia, 2014, vol. 96, p. 8-17. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature