Botanical species · safety record

Lepidium sativum

The EFSA Compendium of Botanicals holds 3 constituent measurements and 1 genotoxicity assay for Lepidium sativum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Lepidium sativum L.

3Constituent measurements

1Safety records

3Cited sources

4Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 4 licensed products naming Lepidium sativum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Seed
Seed(s)

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Aerial part of plants	Solvent extraction	—	—	Resolve DOI
Coumarins	Aerial part of plants	Solvent extraction	—	—	Resolve DOI
Glucotropaeolin	Seed	Solvent extraction	80 Milligram/gram	HPLC with standard detection methods	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro	Other	—	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Nebo, Liliane., Varela, Rosa M., Molinillo, Jose M. G., Sampaio, Olivia M., Severino, Vanessa G. P., Cazal, Cristiane M., das Gracas Fernandes da Silva, Maria Fatima., Fernandes, Joao B., Macias, Francisco A. Phytotoxicity of alkaloids, coumarins and flavonoids isolated from 11 species belonging to the Rutaceae and Meliaceae families. PHYTOCHEMISTRY LETTERS, 2014, vol. 8, p. 226-232. DOI
Hassan, A. M., Alam, S. S., Abdel-Aziem, S. H., Ahmed, K. A. Benzo-a-pyrene induced genotoxicity and cytotoxicity in germ cells of mice: intervention of radish and cress. Journal of Genetic Engineering and Biotechnology, 2011, p. 65-72.
Kassie, F., Rabot, S., Uhl, M., Huber, W., Qin, HM., Helma, C., Schulte-Hermann, R., Knasmuller, S. Chemoprotective effects of garden cress (Lepidium sativum) and its constituents towards 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ)-induced genotoxic effects and colonic preneoplastic lesions. CARCINOGENESIS, 2002, vol. 23, no. 7, p. 1155-1161. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature