Botanical species · safety record

Leucaena leucocephala

The EFSA Compendium of Botanicals holds 10 constituent measurements and 4 adverse-effect records for Leucaena leucocephala. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Leucaena leucocephala (Lam.) de Wit

10Constituent measurements

4Safety records

7Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI
Mimosine	Seed	Solvent extraction	145 Gram/kilogram	—	Resolve DOI
Mimosine	Leaves	Solvent extraction	25 Gram/kilogram	Unspecified	Resolve DOI
Proanthocyanidins (condensed tannins)	Unspecified	—	≤ 43 Gram/kilogram	Unspecified	Resolve DOI
Proanthocyanidins (condensed tannins)	Unspecified	—	≥ 30 Gram/kilogram	Unspecified	Resolve DOI
Cyanide	Leaves	Solvent extraction	14.2 Microgram/gram	Phytochemical screening	No resolvable identifier
Mimosine	Leaves	Solvent extraction	≥ 1.25 Percent	—	No resolvable identifier
Oxalates	Leaves	Solvent extraction	0.126 Percent	Phytochemical screening	No resolvable identifier
Phytic acid	Leaves	Solvent extraction	18.7 Percent	Phytochemical screening	No resolvable identifier
Tannins	Leaves	Solvent extraction	≥ 0.77 Percent	—	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Musclo-skeletal	Skin/subcutis	Leaves	—	Cattle (as animal)	Other	Resolve DOI
Other toxicities	Glandular	Aerial part of plants	—	Goat (as animal)	Case report	Resolve DOI
Hepatotoxicity	Liver	Leaves	Drying (dehydration)	Rabbit (as animal)	Subchronic	No resolvable identifier
Reproductive	Glandular: thyroid	Leaves	Fresh	Goat (as animal)	Subchronic	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

DMELLO, JPF. CHEMICAL CONSTRAINTS TO THE USE OF TROPICAL LEGUMES IN ANIMAL NUTRITION. ANIMAL FEED SCIENCE AND TECHNOLOGY, 1992, vol. 38, no. 2-3, p. 237-261. DOI
Abatan, M. O., Arowolo, R. O., Olurunsogo, O. O. Phytochemical analysis of some commonly occurring poisonous plants in Nigerian pastures . Tropical veterinarian, 1997, vol. 15, no. 1-2, p. 49-54.
Fayemi, P. O., Onwuka, C. F., I., Isah, O. A., Jegede, A., V., Arigbede, O. M., Muchenje, V. Effects of mimosine and tannin toxicity on rabbits fed processed Leucaena leucocephala (Lam) De Wit. leaves . African journal of agricultural research, 2011, vol. 6, no. 17, p. 4081-4085.
Bhatia, Harpreet., Manhas, R. K., Kumar, Kewal., Magotra, Rani. Traditional knowledge on poisonous plants of Udhampur district of Jammu and Kashmir, India . Journal of ethnopharmacology, 2014, vol. 152, no. 1, p. 207-216. DOI
Peixoto, Paulo Vargas., Franca, Ticiana Nascimento., Cunha, Bernardo Melo., Albernaz Mattos Tavares, Danielle Valadao., Brito, Marilene Farias. Spontaneous poisoning by Leucaena leucocephala in a goat from Rio de Janeiro State, Brazil . Ciencia rural, 2008, vol. 38, no. 2, p. 551-555. DOI
Sastry, M. S., Singh, Rajendra. Toxic effects of subabul (Leucaena leucocelphala) on the thyroid and reproduction of female goats . Indian journal of animal sciences, 2008, vol. 78, no. 3, p. 251-253.
Villasenor, IM., Gajo, RMT., Gonda, RC. Bioactivity studies on the alkaloid extracts from seeds of Leucaena leucocephala . Phytotherapy research, 1997, vol. 11, no. 8, p. 615-617. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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