Botanical species · safety record

Ligularia dentata

The EFSA Compendium of Botanicals holds 2 constituent measurements and 1 adverse-effect record for Ligularia dentata. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Ligularia dentata (A.Gray) Hara

2Constituent measurements

1Safety records

2Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Clivorine	Live plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Ligularidine	Live plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	Liver	—	—	Rat (as animal)	Chronic/long term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Asada, Yoshihisa., Furuya, Tsutomu. Studies on constituents of crude drugs. XV. New pyrrolizidine alkaloids from Ligularia dentata. Chemical pharmaceutical bulletin, 1984, p. 475-482.
KUHARA, K., TAKANASHI, H., HIRONO, I., FURUYA, T., ASADA, Y. CARCINOGENIC ACTIVITY OF CLIVORINE, A PYRROLIZIDINE ALKALOID ISOLATED FROM LIGULARIA-DENTATA. CANCER LETTERS, 1980, vol. 10, no. 2, p. 117-122. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature