Botanical species · safety record
Ligusticum officinale
The EFSA Compendium of Botanicals holds 3 constituent measurements and 1 genotoxicity assay for Ligusticum officinale. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Ligusticum officinale (Makino) Kitag
Also recorded as
Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.
Regulatory presence
No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.
What the records describe
Constituents measured
- Falcarindiol1
- Phthalides1
- Z-ligustilide1
Plant parts
- Unspecified2
- Roots and other underground parts1
Preparations
- Drying (dehydration)1
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Falcarindiol | Unspecified | — | — | Unspecified | Resolve DOI |
| Z-ligustilide | Unspecified | — | — | Unspecified | Resolve DOI |
| Phthalides | Roots and other underground parts | Drying (dehydration) | — | GC-MS | No resolvable identifier |
Genotoxicity testing
Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.
| Outcome | Endpoint | Test | Tested organism | Metabolic activation | Source |
|---|---|---|---|---|---|
| Positive | gene mutation | bacterial reverse mutation assay | Salmonella typhimurium (as organism) | With | Resolve DOI |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Yoon, Wonho. Genotoxicological Safety Evaluation of the Solvent Extracts for Medicinal Herbs that are of Highly Domestic Spendings . The korean journal of food and nutrition, 2013, vol. 26, no. 4, p. 814-823. DOI
- Chung, MS. Volatile compounds of Cnidium officinale M-AKINO. Food science and biotechnology, 2004, vol. 13, no. 5, p. 603-608.
- Wu, Zhouwei., Uchi, Hiroshi., Morino-Koga, Saori., Shi, Weimin., Furue, Masutaka. Z-ligustilide ameliorated ultraviolet B-induced oxidative stress and inflammatory cytokine production in human keratinocytes through upregulation of Nrf2/HO-1 and suppression of NF-kappa B pathway . Experimental dermatology, 2015, vol. 24, no. 9, p. 703-708. DOI
- Kim, JM., Lee, P., Son, D., Kim, H., Kim, SY. Falcarindiol inhibits nitric oxide-mediated neuronal death in lipopolysaccharide-treated organotypic hippocampal cultures . Neuroreport, 2003, vol. 14, no. 15, p. 1941-1944. DOI
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
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