Botanical species · safety record

Lippia alba

The EFSA Compendium of Botanicals holds 24 constituent measurements and 1 adverse-effect record for Lippia alba. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Lippia alba (Mill.) N.E.Br. ex Britton & P.Wilson

24Constituent measurements

1Safety records

10Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
1,8-cineole	Leaves	Essential oil	8.8 Percent	GC-MS	Resolve DOI
1,8-cineole	Leaves	Essential oil	≥ 2.38 Percent	GC-MS	Resolve DOI
1,8-cineole	Leaves	Essential oil	≤ 9.22 Percent	GC-MS	Resolve DOI
Carvone	Aerial part of plants	Essential oil	36.7 Percent	GC-MS	Resolve DOI
Carvone	Leaves	Essential oil	≥ 5.53 Percent	GC-MS	Resolve DOI
Carvone	Leaves	Essential oil	≤ 78.46 Percent	GC-MS	Resolve DOI
Carvone	Leaves	Essential oil	≥ 1.16 Percent	GC-MS	Resolve DOI
Carvone	Leaves	Essential oil	≤ 77.74 Percent	GC-MS	Resolve DOI
Carvone	Roots and other underground parts	Solvent extraction	23.7 Percent	GC-MS	Resolve DOI
Myrcene	Leaves	Essential oil	≥ 1.75 Percent	GC-MS	Resolve DOI
Myrcene	Leaves	Essential oil	≤ 5.07 Percent	GC-MS	Resolve DOI
Myrcene	Leaves	Essential oil	≥ 1.27 Percent	GC-MS	Resolve DOI
Myrcene	Leaves	Essential oil	≤ 52.03 Percent	GC-MS	Resolve DOI
P-menth-1-en-3-one	Aerial part of plants	Essential oil	2.7 Percent	GC-MS	Resolve DOI
P-mentha-1,4(8)-dien-3-one	Aerial part of plants	Essential oil	5 Percent	GC-MS	Resolve DOI
Tannins	Unspecified	Solvent extraction	18.9 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
1,8-cineole	Aerial part of plants	Essential oil	≥ 3.1 Percent	—	No resolvable identifier
1,8-cineole	Aerial part of plants	Essential oil	≤ 34.9 Percent	—	No resolvable identifier
Camphor	Unspecified	Essential oil	—	—	No resolvable identifier
Dihydrocarvone	Unspecified	Essential oil	—	—	No resolvable identifier
Myrcene	Leaves	Essential oil	26.4 Percent	GC-MS	No resolvable identifier
Myrcene	Aerial part of plants	Essential oil	2.38 Percent	Gaschromatography (GC)	No resolvable identifier
P-menth-1-en-3-one	Leaves	Essential oil	4.4 Percent Area	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
P-mentha-1,4(8)-dien-3-one	Leaves	Essential oil	4.3 Percent Area	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic	Aerial part of plants	Essential oil (as part-nature)	Rat (as animal)	Acute toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Neto, Antonio C., Netto, Joaquim C., Pereira, Paulo S., Pereira, Ana M. S., Taleb-Contini, Silvia H., Franca, Suzelei C., Marques, Marcia O. M., Beleboni, Rene O. The role of polar phytocomplexes on anticonvulsant effects of leaf extracts of Lippia alba (Mill.) NE Brown chemotypes . Journal of pharmacy and pharmacology, 2009, vol. 61, no. 7, p. 933-939. DOI
Fester, G. A., Martinuzzi, E. A., Retamar, J. A., Ricciardi, A. I. A. Essential oils from Argentine plants. Boletin de la academia nacional de ciencias (argentina), 1958, p. 189-208.
Andrea Lopez, Molkary., Stashenko, Elena E., Luis Fuentes, Jorge. Chemical composition and antigenotoxic properties of Lippia alba essential oils . Genetics and molecular biology, 2011, vol. 34, no. 3, p. 479-488.
Zapata, Bibiana., Betancur-Galvis, Liliana., Duran, Camilo., Stashenko, Elena. Cytotoxic activity of Asteraceae and Verbenaceae family essential oils. Journal of essential oil research, 2014, vol. 26, no. 1, p. 50-57. DOI
Pansera, M.R., Santos, A.C.A., Paese, K., Wasum, R., Rossato, M., Rota, L.D., Pauletti, G.F., Serafini, L.A. An�lise de taninos totais em plantas arom�ticas e medicinais cultivadas no Nordeste do Rio Grande do Sul . Revista brasileira de farmacognosia, 2003, vol. 13, no. 1, p. 17-22. DOI
Singh, G., Pandey, S.K., Leclercq, P.A., Sperkova, J. Studies on essential oils. Part 15. GC/MS analysis of chemical constituents of leaf oil of Lippia alba (Mill.) from north India. Journal of essential oil research, 1999, vol. 11, no. 2, p. 206-208.
Blank, Arie Fitzgerald., Camelo, Lidia Cristina Alves., Arrigoni-Blank, Maria de Fatima., Pinheiro, Jose Baldin., Andrade, Thiago Matos., Niculau, Edenilson dos Santos., Alves, Pericles Barreto. Chemical Diversity in Lippia alba (Mill.) N. E. Brown Germplasm.. Thescientificworldjournal, 2015, vol. 2015, p. 321924-321924. DOI
Sena Filho, Jose G., Duringer, Jennifer M., Souza, Ivone A., da Cunha, Emidio V. L., Craig, A. Morrie., Silva, Marcelo S., Barbosa-Filho, Jose M., Xavier, Haroudo S. Phytochemistry and acute toxicity from the roots of Lippia alba. Pharmaceutical biology, 2009, vol. 47, no. 2, p. 142-145. DOI
Aular, Y., Villamizar, M., P�rez, Y., P�rez, V. Chemical composition and oral acute toxicity of Lippia alba essential oil in mice Composici�n qu�mica y toxicidad aguda oral del aceite esencial de Lippia alba en ratones . Salus, 2016, vol. 20, no. 1, p. 43-51.
Zoghbi, MDGB., Andrade, EHA., Santos, AS., Silva, MHL., Maia, JGS. Essential oils of Lippia alba (Mill.) N. E. Br growing wild in the Brazilian Amazon . Flavour and fragrance journal, 1998, vol. 13, no. 1, p. 47-48.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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