Botanical species · safety record
Lophophora williamsii
The EFSA Compendium of Botanicals holds 12 constituent measurements and 1 adverse-effect record for Lophophora williamsii. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Lophophora williamsii (Lem. ex Salm-Dyck) J.M.Coult.
Also recorded as
Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.
Regulatory presence
No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.
What the records describe
Constituents measured
- Mescaline7
- Alkaloids1
- Homopiperonylamine1
- Isoquinoline alkaloids1
- Lobivine1
- Lophophine1
Plant parts
- Live plants6
- Aerial part of plants4
- Stem2
- stalk2
Preparations
- Solvent extraction8
- Fresh1
Effect types
- Neurotoxicity1
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Alkaloids | Live plants | Solvent extraction | — | HPLC-DAD | Resolve DOI |
| Isoquinoline alkaloids | Live plants | Solvent extraction | — | HPLC-DAD | Resolve DOI |
| Mescaline | Live plants | Solvent extraction | ≥ 680 Milligram/100 gram | HPLC-DAD | Resolve DOI |
| Mescaline | Live plants | Solvent extraction | ≤ 1010 Milligram/100 gram | HPLC-DAD | Resolve DOI |
| Mescaline | Stem / stalk | Solvent extraction | ≥ 12.7 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Mescaline | Stem / stalk | Solvent extraction | ≤ 48.3 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Homopiperonylamine | Aerial part of plants | — | — | — | No resolvable identifier |
| Lobivine | Aerial part of plants | — | — | — | No resolvable identifier |
| Lophophine | Aerial part of plants | — | — | — | No resolvable identifier |
| Mescaline | Live plants | Solvent extraction | ≥ 0.0147 Percent | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Mescaline | Live plants | Solvent extraction | ≤ 5.5 Percent | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Mescaline | Aerial part of plants | Fresh | 2.55 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
Recorded adverse effects
Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.
| Effect | Target tissue | Plant part | Preparation | Test organism | Test type | Source |
|---|---|---|---|---|---|---|
| Neurotoxicity | — | — | — | Human (as organism) | Case report | Resolve DOI |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- HELMLIN, HJ., BOURQUIN, D., BRENNEISEN, R. DETERMINATION OF PHENYLETHYLAMINES IN HALLUCINOGENIC CACTUS SPECIES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH PHOTODIODE-ARRAY DETECTION . Journal of chromatography, 1992, vol. 623, no. 2, p. 381-385. DOI
- Carstairs, Shaun D., Cantrell, F. Lee. Peyote and mescaline exposures: a 12-year review of a statewide poison center database . Clinical toxicology, 2010, vol. 48, no. 4, p. 350-353. DOI
- Bruhn, Jan G., El-Seedi, Hesharn R., Stephanson, Nikolai., Beck, Olof., Shulgin, Alexander T. Ecstasy analogues found in cacti. Journal of psychoactive drugs, 2008, vol. 40, no. 2, p. 219-222.
- Klein, Molly T., Kalam, M., Trout, Keeper., Fowler, Norma., Terry, Martin. MESCALINE CONCENTRATIONS IN THREE PRINCIPAL TISSUES OF LOPHOPHORA WILLIAMSII (CACTACEAE): IMPLICATIONS FOR SUSTAINABLE HARVESTING PRACTICES . Haseltonia, 2015, no. 20, p. 34-42.
- Aragane, Masako., Sasaki, Yohei., Nakajima, Jun'ichi., Fukumori, Nobutaka., Yoshizawa, Masao., Suzuki, Yukiko., Kitagawa, Shigemi., Mori, Ken'ichiro., Ogino, Shuzo., Yasuda, Ichiro., Nagumo, Seiji. Peyote identification on the basis of differences in morphology, mescaline content, and trnL/trnF sequence between Lophophora williamsii and L. diffusa . Journal of natural medicines, 2011, vol. 65, no. 1, p. 103-110. DOI
- Gennaro, MC., Gioannini, E., Giacosa, D., Siccardi, D. Determination of mescaline in hallucinogenic Cactaceae by ion-interaction HPLC. . Analytical letters, 1996, vol. 29, no. 13, p. 2399-2409.
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
Continue
Europe PMC
Every record indexed for this species, resolvable and re-runnable.
All speciesSubstance index
Search and browse every species this world holds under source and hash.
Before anything elseSafety Centre
Interactions, contraindications and the escalation boundary this world does not cross.
In its own termsTraditions
How the living traditions approach preparation, use and context.