Botanical species · safety record

Lupinus luteus

The EFSA Compendium of Botanicals holds 18 constituent measurements, 5 adverse-effect records and 2 genotoxicity assays for Lupinus luteus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Lupinus luteus L.

18Constituent measurements

7Safety records

8Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Isoflavones	Roots and other underground parts	—	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
(-)-sparteine	Seed	—	≥ 2 Microgram/gram	GC-MS	No resolvable identifier
(-)-sparteine	Seed	—	≤ 50 Microgram/gram	GC-MS	No resolvable identifier
Alkaloids	Seed	—	≥ 230 Milligram/kilogram	Unspecified	No resolvable identifier
Alkaloids	Seed	—	≤ 1300 Milligram/kilogram	Unspecified	No resolvable identifier
Gramine	Seed	—	≥ 0.13 Gram/kilogram	Unspecified	No resolvable identifier
Gramine	Seed	—	≤ 893 Microgram/gram	GC-MS	No resolvable identifier
Gramine	Seed	—	≥ 450 Microgram/gram	GC-MS	No resolvable identifier
Isoflavones	Leaves	—	≥ 0.99 Milligram/gram	Unspecified	No resolvable identifier
Isoflavones	Leaves	—	≤ 1.28 Milligram/gram	Unspecified	No resolvable identifier
Isoflavones	Stem / stalk	—	≥ 0.6 Milligram/gram	Unspecified	No resolvable identifier
Isoflavones	Stem / stalk	—	≤ 0.7 Milligram/gram	Unspecified	No resolvable identifier
Isoflavones	Flower	—	≥ 8.41 Milligram/gram	Unspecified	No resolvable identifier
Isoflavones	Flower	—	≤ 8.53 Milligram/gram	Unspecified	No resolvable identifier
Isoflavones	Flower	—	≥ 12.51 Milligram/gram	Unspecified	No resolvable identifier
Isoflavones	Flower	—	≤ 12.93 Milligram/gram	Unspecified	No resolvable identifier
Lupinine	Seed	—	≥ 3 Microgram/gram	GC-MS	No resolvable identifier
Lupinine	Seed	—	≤ 12 Microgram/gram	GC-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Developmental	Digestive	—	—	Rainbow trout (as animal)	Short-term toxicity	Resolve DOI
Hemopoietic	Cardiovascular / haematological	Seed	—	Rat (as animal)	Subchronic	No resolvable identifier
Other toxicities	—	Seed	—	Rat (as animal)	Subchronic	No resolvable identifier
Other toxicities	—	Seed	—	Rat (as animal)	Subchronic	No resolvable identifier
Reproductive	—	Seed	—	Rat (as animal)	Reproduction toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro	House mouse (as animal)	Not applicable	Resolve DOI
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Other	—	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Rucinska, A., Gabryelak, T. Effect of genistein-8-C-glucoside from Lupinus luteus on DNA damage assessed using the comet assay in vitro. Cell biology international, 2009, vol. 33, no. 2, p. 247-252. DOI
Glencross, B., Evans, D., Rutherford, N., Hawkins, W., McCafferty, P., Dods, K., Jones, B., Harris, D., Morton, L., Sweetingham, M., Sipsas, S. The influence of the dietary inclusion of the alkaloid gramine, on rainbow trout (Oncorhynchus mykiss) growth, feed utilisation and gastrointestinal histology. Aquaculture, 2006, vol. 253, no. 1-4, p. 512-522. DOI
Reinhard, Hans., Rupp, Heinz., Sager, Fritz., Streule, Michael., Zoller, Otmar. Quinolizidine alkaloids and phomopsins in lupin seeds and lupin containing food. Journal of Chromatography A, 2006, p. 353-360.
Wasilewko, J., Buraczewska, L. Chemical composition including content of amino acids, minerals and alkaloids in seeds of three lupin species cultivated in Poland . Journal of animal and feed sciences, 1999, vol. 8, no. 1, p. 1-12.
Laman, M. A. Isoflavones as a possible index of the food value of Lupinus luteus foliage. Vestsi akademii navuk bssr, seryya biyalagichnykh navuk, 1972, p. 40-41.
Rucinska, R., Sobkowiak, R., Gwozdz, EA. Genotoxicity of lead in lupin root cells as evaluated by the comet assay. CELLULAR & MOLECULAR BIOLOGY LETTERS, 2004, vol. 9, no. 3, p. 519-528.
Pastuszewska, Barbara., Ochtabinska, Anna., Lechowski, R. Response of animals to dietary gramine. II. Effects of feeding high-gramine yellow lupin seeds on reproductive performance of rats and on selected hematological and biochemical parameters in offspring. Archives of animal nutrition, 2001, p. 17-24.
Laman, N.A., Volynets, A.P. Isoflavones of the roots of Lupinus luteus. Chemistry of natural compounds, 1975, vol. 10, no. 2, p. 175-177. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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