Botanical species · safety record

Manihot esculenta

The EFSA Compendium of Botanicals holds 4 constituent measurements and 9 adverse-effect records for Manihot esculenta. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Manihot esculenta Crantz

4Constituent measurements

9Safety records

7Cited sources

2Licensed products (Canada)

Also recorded as

Manihot utilissima Pohl

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 2 licensed products naming Manihot esculenta as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Root fibre

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Cyanogenic glycosides	Roots and other underground parts used as staple food	Solvent extraction	71.69 Microgram/millilitre	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Hydrogen cyanide (cyanides expressed as hydrogen cyanide)	Roots and other underground parts used as staple food	—	21 Milligram/kilogram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Cyanide	Roots and other underground parts used as staple food	Powder	≤ 45 Milligram/100 gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Cyanide	Roots and other underground parts used as staple food	Powder	≥ 28 Milligram/100 gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hemopoietic	—	Roots and other underground parts used as staple food	Solvent extraction	Rat (as animal)	Subchronic	Resolve DOI
Hemopoietic	—	Roots and other underground parts used as staple food	Solvent extraction	Rat (as animal)	Subchronic	Resolve DOI
None	—	Roots and other underground parts used as staple food	—	Rat (as animal)	Subchronic	Resolve DOI
None	—	Roots and other underground parts used as staple food	—	Rat (as animal)	Subchronic	Resolve DOI
Systemic	Cardiovascular / haematological	Roots and other underground parts used as staple food	—	Sheep (as animal)	Short-term toxicity	Resolve DOI
Systemic	Cardiovascular / haematological	Roots and other underground parts used as staple food	—	Sheep (as animal)	Short-term toxicity	Resolve DOI
Digestive	Digestive	Roots and other underground parts used as staple food	—	Human (as organism)	Case report	No resolvable identifier
Hepatotoxicity	Liver	Roots and other underground parts used as staple food	—	Human (as organism)	Case report	No resolvable identifier
Systemic	—	Roots and other underground parts used as staple food	—	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

AKANJI, AO., FAMUYIWA, OO. THE EFFECTS OF CHRONIC CASSAVA CONSUMPTION, CYANIDE INTOXICATION AND PROTEIN-MALNUTRITION ON GLUCOSE-TOLERANCE IN GROWING RATS. British journal of nutrition, 1993, vol. 69, no. 1, p. 269-276. DOI
Adam Shama, I.Y., Ahmed Wasma, A.A. Evaluation of the toxicity of manihot esculenta on wistar rats after traditional sudanese processing. Journal of pharmacology and toxicology, 2011, vol. 6, no. 4, p. 418-426. DOI
Akintonwa, Alade., Tunwashe, O., Onifade, A. Fatal and non-fatal acute poisoning attributed to cassava-based meal. Acta horticulturae, 1994, vol. 1994), p. 285-288.
Sriapha, Charuwan., Tongpoo, Achara., Wongvisavakorn, Sunun., Rittilert, Panee., Trakulsrichai, Satariya., Srisuma, Sahaphume., Wananukul, Winai. PLANT POISONING IN THAILAND: A 10-YEAR ANALYSIS FROM RAMATHIBODI POISON CENTER. Southeast asian journal of tropical medicine and public health, 2015, vol. 46, no. 6, p. 1063-1076.
Silva, Valdir C., de Oliveira, Luciana A., Lacerda, Maira dos S. C., Pimentel, Luciano A., Santos, Wiles S., e Macedo, Juliana Targino S. A., Riet-Correa, Franklin., Pedroso, Pedro M. O. Experimental poisoning by cassava wastewater in sheep. Pesquisa veterinaria brasileira, 2017, vol. 37, no. 11, p. 1241-1246. DOI
Cressey, Peter., Saunders, Darren., Goodman, Janet. Cyanogenic glycosides in plant-based foods available in New Zealand. Food additives and contaminants part a-chemistry analysis control exposure & risk assessment, 2013, vol. 30, no. 11, p. 1946-1953. DOI
Fukushima, Andre Rinaldi., Nicoletti, Maria Aparecida., Rodrigues, Almir Junior., Pressutti, Caroline., Almeida, Jeandro., Brandao, Tamires., Ito, Rosilene Kinue., Leoni, Luis Antonio Bafille., Spinosa, Helenice De Souza. Cassava flour: quantification of cyanide content. Food and nutrition sciences, 2016, vol. 7, no. 7, p. 592-599.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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