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Botanical species · safety record

Medicago lupulina

The EFSA Compendium of Botanicals holds 17 constituent measurements and 1 adverse-effect record for Medicago lupulina. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Medicago lupulina L.

17Constituent measurements
1Safety records
7Cited sources
0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

  • Saponins8
  • Genistin2
  • Formononetin1
  • Genistein1
  • Irilone1
  • Pratensein1
  • Prunetin1
  • Puerarin1
  • Triterpene saponins1

Plant parts

  • Aerial part of plants8
  • Live plants3
  • Leaves2
  • Seed2
  • Flower1
  • Roots and other underground parts1
  • Stem1
  • stalk1

Preparations

  • Solvent extraction17

Effect types

  • Digestive1

Target tissues

  • Digestive1

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
Triterpene saponinsRoots and other underground partsSolvent extraction—Standard Chromatographic tests (paper- thin layer- and column chromatography)Resolve DOI
FormononetinAerial part of plantsSolvent extraction5.1 Milligram/kilogramHPLC-DADNo resolvable identifier
GenisteinAerial part of plantsSolvent extraction111.1 Milligram/kilogramHPLC-DADNo resolvable identifier
GenistinAerial part of plantsSolvent extraction22.5 Milligram/kilogramHPLC-DADNo resolvable identifier
GenistinAerial part of plantsSolvent extraction246.7 Nanogram/millilitreHPLC with standard detection methodsNo resolvable identifier
IriloneAerial part of plantsSolvent extraction3 Milligram/kilogramHPLC-DADNo resolvable identifier
PratenseinAerial part of plantsSolvent extraction9.6 Milligram/kilogramHPLC-DADNo resolvable identifier
PrunetinAerial part of plantsSolvent extraction2.5 Milligram/kilogramHPLC-DADNo resolvable identifier
PuerarinAerial part of plantsSolvent extraction0.2 Milligram/kilogramHPLC-DADNo resolvable identifier
SaponinsLeavesSolvent extraction—UnspecifiedNo resolvable identifier
SaponinsLive plantsSolvent extraction3.5 PercentGravimetric testsNo resolvable identifier
SaponinsLive plantsSolvent extraction—UnspecifiedNo resolvable identifier
SaponinsLeavesSolvent extraction3 PercentGravimetric testsNo resolvable identifier
SaponinsSeedSolvent extraction—UnspecifiedNo resolvable identifier
SaponinsSeedSolvent extraction3 PercentGravimetric testsNo resolvable identifier
SaponinsStem / stalkSolvent extraction1.8 PercentGravimetric testsNo resolvable identifier
SaponinsFlowerSolvent extraction1.7 PercentGravimetric testsNo resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

EffectTarget tissuePlant partPreparationTest organismTest typeSource
DigestiveDigestiveLive plants—House mouse (as animal)Not reportedNo resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Krzymanska, Jadwiga., Waligora, Danuta. Significance of saponins in resistance of alfalfa against green pea aphid (Acyrthosiphon pisum Harris). Prace naukowe instytutu ochrony roslin, 1983, p. 153-160.
  2. OLESZEK, W., PRICE, KR., FENWICK, GR. TRITERPENE SAPONINS FROM THE ROOTS OF MEDICAGO-LUPULINA L (BLACK MEDICK TREFOIL) . Journal of the science of food and agriculture, 1988, vol. 43, no. 4, p. 289-297. DOI
  3. Gorski, Piotr M., Jurzysta, Marian., Burda, Stanislaw., Oleszek, Wieslaw., Ploszynski, Michal. Studies of Medicago lupulina saponins. IV. Variation in the saponin content of M. lupulina. Acta societatis botanicorum poloniae, 1984, p. 543-550.
  4. GORSKI, PM. ANTINUTRITIONAL PROPERTIES OF MEDICAGO LUPULINA SAPONINS AS RELATED TO THEIR CHEMICAL-COMPOSITION . Abstracts of papers of the american chemical society, 1985, vol. 190, no. SEP, p. 103-AGD.
  5. Cunha, Sara C., Faria, Miguel A., Sousa, Tiago., Nunes, Eugenia. Isoflavone determination in spontaneous legumes identified by DNA barcodes. Food chemistry, 2012, p. 2262-2267.
  6. Jurzysta, Marian. Effect of saponins isolated from seeds of lucerne on germination and growth of cereal seedlings. Zeszyty naukowe uniwersytetu w toruniu, nauki matematyczno-przyrodnicze, biologia, 1970, p. 253-256.
  7. Hanganu, Daniela., Vlase, Laurian., Olah, Neli. LC/MS ANALYSIS OF ISOFLAVONES FROM FABACEAE SPECIES EXTRACTS. Farmacia, 2010, vol. 58, no. 2, p. 177-183.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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