Botanical species · safety record

Melaleuca alternifolia

The EFSA Compendium of Botanicals holds 5 constituent measurements and 1 adverse-effect record for Melaleuca alternifolia. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Melaleuca alternifolia (Maiden & Betche) Cheel

5Constituent measurements

1Safety records

5Cited sources

269Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 269 licensed products naming Melaleuca alternifolia as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Branch(es)
Essential oil from leaf
Herb top flowering
Leaf
Leaf extract
Leaf oil
Leaf/Leaves
Leafy twigs

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
1,8-cineole	Leaves	Essential oil	3.64 Percent	GC-MS	Resolve DOI
1,8-cineole	Leaves	Essential oil	—	Gaschromatography (GC)	Resolve DOI
1,8-cineole	Aerial part of plants	Essential oil	3 Percent	GC-MS	Resolve DOI
Methyleugenol	Leaves	Essential oil	≤ 1230 ppm	GC-MS	No resolvable identifier
Methyleugenol	Leaves	Essential oil	≥ 86 ppm	GC-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic	—	Essential oil (as part-nature)	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

JACOBS, MR., HORNFELDT, CS. MELALEUCA OIL POISONING. Journal of toxicology-clinical toxicology, 1994, vol. 32, no. 4, p. 461-464.
Shepherd, Mervyn., Savins, Dale., Dowell, Ashley., Morrow, Samantha., Allen, Gareth., Southwell, Ian. Ecotype variation of methyl eugenol content in tea tree (Melaleuca alternifolia and Melaleuca linariifolia). Chemistry & biodiversity, 2017, p. Ahead of Print.
Rolli, Enrico., Marieschi, Matteo., Maietti, Silvia., Sacchetti, Gianni., Bruni, Renato. Comparative phytotoxicity of 25 essential oils on pre- and post-emergence development of Solanum lycopersicum L.: A multivariate approach . Industrial crops and products, 2014, vol. 60, p. 280-290. DOI
Russell, MF., Southwell, IA. Monoterpenoid accumulation in 1,8-cineole, terpinolene and terpinen-4-ol chemotypes of Melaleuca alternifolia seedlings . Phytochemistry, 2003, vol. 62, no. 5, p. 683-689. DOI
Pereira, Tais Susane., de Sant'Anna, Juliane Rocha., Silva, Expedito Leite., Pinheiro, Antonio Lelis., Alves de Castro-Prado, Marialba A. In vitro genotoxicity of Melaleuca alternifolia essential oil in human lymphocytes . Journal of ethnopharmacology, 2014, vol. 151, no. 2, p. 852-857. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature