Botanical species · safety record

Melia azedarach

The EFSA Compendium of Botanicals holds 11 constituent measurements and 7 adverse-effect records for Melia azedarach. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Melia azedarach L.

11Constituent measurements

7Safety records

10Cited sources

111Licensed products (Canada)

Also recorded as

Melia toosendan Siebold & Zucc.
Melia dubia Cav.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 111 licensed products naming Melia azedarach as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Fruit
Leaf
Stem bark

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Limonoids	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Limonoids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Limonoids	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Limonoids	Bark	Solvent extraction	—	Unspecified	Resolve DOI
Limonoids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
4-hydroxybenzaldehyde	Unspecified	Solvent extraction	—	Unspecified	No resolvable identifier
4-hydroxybenzoic acid	Unspecified	Solvent extraction	—	Unspecified	No resolvable identifier
Hydroxymethylfurfural	Unspecified	Solvent extraction	—	Unspecified	No resolvable identifier
Lignans	Unspecified	Solvent extraction	—	Unspecified	No resolvable identifier
Medioresinol	Unspecified	Solvent extraction	—	Unspecified	No resolvable identifier
Pinoresinol	Unspecified	Solvent extraction	—	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Unspecified	—	Animals (as animal)	Case report	Resolve DOI
Digestive	Digestive	Fruit unspecified	—	—	Case report	Resolve DOI
Musclo-skeletal	—	Unspecified	—	Animals (as animal)	Case report	Resolve DOI
Neurotoxicity	Neurologic	Unspecified	—	Animals (as animal)	Case report	Resolve DOI
Neurotoxicity	Neurologic	Fruit unspecified	—	Dog (as animal)	Case report	Resolve DOI
Neurotoxicity	Neurologic	Fruit unspecified	—	—	Case report	Resolve DOI
Reproductive	—	Fruit unspecified	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Ferreiro, D., Orozco, J. P., Miron, C., Real, T., Hernandez-Moreno, D., Soler, F., Perez-Lopez, M. Chinaberry Tree (Melia azedarach) Poisoning in Dog: A Case Report. Topics in companion animal medicine, 2010, vol. 25, no. 1, p. 64-67. DOI
Cooper, Ross G. Poisoning in ostriches following ingestion of toxic plants - field observations. TROPICAL ANIMAL HEALTH AND PRODUCTION, 2007, vol. 39, no. 6, p. 439-442. DOI
Botha, C. J., Penrith, M. -L. Poisonous plants of veterinary and human importance in southern Africa. JOURNAL OF ETHNOPHARMACOLOGY, 2008, vol. 119, no. 3, p. 549-558. DOI
Roop, J.K., Dhaliwal, P.K. Effect of Melia azedarach Linn seed extract on estrous cycle and reproductive performance in female rats. International journal of pharmtech research, 2015, vol. 8, no. 2, p. 273-279.
Xie, F., Zhang, M., Zhang, C.-F., Wang, Z.-T., Yu, B.-Y. Studies on chemical constituents in fruit of Melia toosendan. Chinese pharmaceutical journal, 2008, vol. 43, no. 14, p. 1066-1069.
Zhang, Qiong., Zhang, Yong-Gang., Li, Qing-Shan., Min, Zhi-Da. Two New Nimbolinin-Type Limonoids from the Fruits of Melia toosendan. Helvetica chimica acta, 2016, vol. 99, no. 6, p. 462-465. DOI
Fukuyama, Yoshiyasu., Nakaoka, Momoko., Yamamoto, Tomoko., Takahashi, Hironobu., Minami, Hiroyuki. Degraded and oxetane-bearing limonoids from the roots of Melia azedarach. Chemical & pharmaceutical bulletin, 2006, vol. 54, no. 8, p. 1219-1222. DOI
Yuan, Chun-Mao., Zhang, Yu., Tang, Gui-Hua., Li, Yan., He, Hong-Ping., Li, Shi-Fei., Hou, Li., Li, Xing-Yao., Di, Ying-Tong., Li, Shun-Lin., Hua, Hui-Ming., Hao, Xiao-Jiang. Cytotoxic Limonoids from Melia azedarach. Planta medica, 2013, vol. 79, no. 2, p. 163-168. DOI
Li, MF., Shi, YL. Toosendanin interferes with pore formation of botulinum toxin type A in PC12 cell membrane . Acta pharmacologica sinica, 2006, vol. 27, no. 1, p. 66-70. DOI
Nakatani, M., Huang, RC., Okamura, H., Iwagawa, T., Tadera, K. Degraded limonoids from Melia azedarach. Phytochemistry, 1998, vol. 49, no. 6, p. 1773-1776. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature