Botanical species · safety record

Melilotus officinalis

The EFSA Compendium of Botanicals holds 11 constituent measurements for Melilotus officinalis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Melilotus officinalis (L.) Pall.

11Constituent measurements

0Safety records

9Cited sources

42Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 42 licensed products naming Melilotus officinalis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Aerial parts
Aerial parts of the plant
Flower
Flower part(s)
Flower tops
Flowering top(s)
Fresh aerial parts in flower without woody stems
Fresh aerial parts in flower, w/o lignified lower stem parts

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
3,4-dihydrocoumarin	Unspecified	Solvent extraction	0.538 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Coumarin	Aerial part of plants	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Coumarins	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Coumarins	Aerial part of plants	Solvent extraction	0.332 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Pterocarpans	Unspecified	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Saponins	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Coumarin	Aerial part of plants	Solvent extraction	46.78 Microgram/millilitre	LC-MS	No resolvable identifier
Coumarins	Aerial part of plants	Solvent extraction	—	GC-MS	No resolvable identifier
Genistin	Aerial part of plants	Solvent extraction	567.2 Nanogram/millilitre	HPLC with standard detection methods	No resolvable identifier
P-coumaric acid	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Umbelliferone	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kubrak, Tomasz., Dresler, Slawomir., Szymczak, Grazyna., Bogucka-Kocka, Anna. Rapid Determination of Coumarins in Plants by Capillary Electrophoresis. Analytical letters, 2015, vol. 48, no. 18, p. 2819-2832. DOI
BOURGAUD, F., POUTARAUD, A., GUCKERT, A. EXTRACTION OF COUMARINS FROM PLANT-MATERIAL (LEGUMINOSAE). Phytochemical analysis, 1994, vol. 5, no. 3, p. 127-132. DOI
Wu, Cai-Xia., Zhao, Guo-Qi., Liu, Da-Lin., Liu, Su-Jiao., Gun, Xiao-Xiao., Tang, Qian. Discovery and Weed Inhibition Effects of Coumarin as the Predominant Allelochemical of Yellow Sweetclover (Melilotus officinalis) . International journal of agriculture and biology, 2016, vol. 18, no. 1, p. 168-175.
Ehlers, D., Platte, S., Bork, WR., Gerard, D., Quirin, KW. HPLC analysis of sweat clover extracts. Deutsche lebensmittel-rundschau, 1997, vol. 93, no. 3, p. 77-79.
Pascual, ME., Carretero, ME., Slowing, KV., Villar, A. Simplified screening by TLC of plant drugs. Pharmaceutical biology, 2002, vol. 40, no. 2, p. 139-143. DOI
Gird, Cerasela Elena., Dutu, Ligia Elena., Popescu, Maria Lidia., Pavel, Mariana., Sterie, Alina Titina. EXPERIMENTAL RESEARCH REGARDING THE ACTIVE EXTRACTS, POLYPHENOLS-STANDARDIZED. NOTE II. MELILOTI HERBA - PHARMACOGNOSTIC ANALYSIS OF THE RAW MATERIAL . Farmacia, 2009, vol. 57, no. 2, p. 184-191.
Yang, J., Wang, L.-L., Zhou, X.-T., Yuan, J.-Z., Zhang, T.-J., Liu, F. Chemical constituents from Melilotus officinalis. Chinese traditional and herbal drugs, 2014, vol. 45, no. 5, p. 622-625. DOI
Hanganu, Daniela., Vlase, Laurian., Olah, Neli. LC/MS ANALYSIS OF ISOFLAVONES FROM FABACEAE SPECIES EXTRACTS. Farmacia, 2010, vol. 58, no. 2, p. 177-183.
Nair, R. M., Whittall, A., Hughes, S. J., Craig, A. D., Revell, D. K., Miller, S. M., Powell, T., Auricht, G. C. Variation in coumarin content of Melilotus species grown in South Australia . New zealand journal of agricultural research, 2010, vol. 53, no. 3, p. 201-213. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature