Botanical species · safety record

Melissa officinalis

The EFSA Compendium of Botanicals holds 3 constituent measurements, 1 adverse-effect record and 1 genotoxicity assay for Melissa officinalis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Melissa officinalis L.

3Constituent measurements

2Safety records

4Cited sources

1,099Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1,099 licensed products naming Melissa officinalis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid

Source material stated

Aerial parts
Aerial stems
Dried aerial part(s)
Dried aerial parts
Dried herb tops
Dried leaf
Flower
Flower and stem

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Polycyclic aromatic hydrocarbons	Leaves	Solvent extraction	321.32 Microgram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Eugenol	Leaves	—	—	Unspecified	No resolvable identifier
Tannins	Unspecified	—	—	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	—	—	Human (as organism)	Case report	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	With and without	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Consolini, A.E., Ragone, M.I. Patterns of self-medication with medicinal plants and related adverse events - A South American survey. Current Drug Safety, 2010, vol. 5, no. 4, p. 333-341. DOI
Abudayyak, Mahmoud., Ozdemir Nath, Ebru., Ozhan, Gul. Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey. TURKISH JOURNAL OF MEDICAL SCIENCES, 2015, vol. 45, no. 3, p. 496-506. DOI
Ulbricht, Catherine., Brendler, Thomas., Gruenwald, Joerg., Kligler, Benjamin., Keifer, David., Abrams, Tracee Rae., Woods, Jen., Boon, Heather., Kirkwood, Catherine DeFranco., Hackman, Dana A., Basch, Ethan., Lafferty, Heather J. Lemon balm (Melissa officinalis L.): an evidence-based systematic review by the Natural Standard Research Collaboration.. Journal of herbal pharmacotherapy, 2005, vol. 5, no. 4, p. 71-114.
Krajian, H., Odeh, A. Polycyclic aromatic hydrocarbons in medicinal plants from Syria. Toxicological and environmental chemistry, 2013, vol. 95, no. 6, p. 942-953. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature