Botanical species · safety record

Mentha x

The EFSA Compendium of Botanicals holds 25 constituent measurements, 1 adverse-effect record and 2 genotoxicity assays for Mentha x. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Mentha x rotundifolia (L.) Huds.

25Constituent measurements

3Safety records

10Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Carvone	Aerial part of plants	Essential oil	60 Percent	Gaschromatography (GC)	Resolve DOI
Dihydrocarvone	Aerial part of plants	Essential oil	69 Percent	Gaschromatography (GC)	Resolve DOI
Myrcene	Aerial part of plants	Solvent extraction	3 Percent	Gaschromatography (GC)	Resolve DOI
Piperitenone oxide	Aerial part of plants	Essential oil	≤ 77 Percent	Gaschromatography (GC)	Resolve DOI
Piperitenone oxide	Aerial part of plants	Essential oil	≥ 64 Percent	Gaschromatography (GC)	Resolve DOI
Piperitone oxide	Aerial part of plants	Essential oil	75 Percent	Gaschromatography (GC)	Resolve DOI
(+)-pulegone	Aerial part of plants	Essential oil	≤ 1.7 Percent	Unspecified	No resolvable identifier
(+)-pulegone	Aerial part of plants	Essential oil	≥ 1.1 Percent	Unspecified	No resolvable identifier
1,8-cineole	Live plants	Essential oil	2.4 Percent	GC-MS	No resolvable identifier
1,8-cineole	Leaves	Essential oil	2.4 Percent	GC-MS	No resolvable identifier
1,8-cineole	Aerial part of plants	Essential oil	2.33 Percent	GC-MS	No resolvable identifier
Cis-piperitone epoxide	Leaves	Essential oil	3.8 Percent	GC-MS	No resolvable identifier
D,l-isomenthone	Aerial part of plants	Essential oil	7 Percent	Unspecified	No resolvable identifier
Epoxides	Leaves	Essential oil	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Menthofuran	Leaves	Essential oil	4.2 Percent	GC-MS	No resolvable identifier
Menthofuran	Leaves	Essential oil	4.2 Percent	GC-MS	No resolvable identifier
Menthone	Leaves	Essential oil	5 Percent	GC-MS	No resolvable identifier
Menthone	Aerial part of plants	Essential oil	≥ 25 Percent	Unspecified	No resolvable identifier
Menthone	Aerial part of plants	Essential oil	≤ 33.7 Percent	Unspecified	No resolvable identifier
Myrcene	Leaves	Essential oil	1.6 Percent	GC-MS	No resolvable identifier
Myrcene	Leaves	Essential oil	1.6 Percent	GC-MS	No resolvable identifier
P-menth-1-en-3-one	Leaves	Essential oil	3.1 Percent	GC-MS	No resolvable identifier
Piperitenone oxide	Aerial part of plants	Essential oil	62 Percent	—	No resolvable identifier
Piperitone oxide	Leaves	Essential oil	3.2 Percent	GC-MS	No resolvable identifier
Safrole	Live plants	Essential oil	1.9 Percent	GC-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	—	Aerial part of plants	Essential oil (as part-nature)	House mouse (as animal)	Acute toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	genome mutation	somatic mutation assay in Drosophila	Drosophila melanogaster (as animal)	No data	Resolve DOI
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	No data	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Baser, K. H. C., Kurkcuoglu, M., Demirci, B., Ozek, T., Tarimcilar, G. Essential oils of Mentha species from Marmara region of Turkey. JOURNAL OF ESSENTIAL OIL RESEARCH, 2012, vol. 24, no. 3, p. 265-272. DOI
Bellakhdar, J., Berrada, M., Holeman, M., Ilidrissi, A., Pinel, R. Qualitative and quantitative analysis of oil of Mentha rotundifolia (L.) Hudson ssp eu-rotundifolia var. typica. Plantes medicinales et phytotherapie, 1983, p. 33-39.
Liu, Mingchun., Li, Zhengguo., Deng, Wei., Wang, Guomin., Yang, Yingwu. Analysis of volatile oil from Mentha rotundifolia (L.) Huds by gas chromatography-mass spectrometry. Jingxi huagong, 2008, p. 1216-1219.
Derwich, E., Benziane, Z., Taouil, R., Senhaji, O., Touzani, M. Comparative essential oil composition of leaves of mentha rotundifolia and mentha pulegium a traditional herbal medicine in Morocco. American-eurasian journal of sustainable agriculture, 2010, vol. 4, no. 1, p. 47-54.
Derwich, E., Benziane, Z., Boukir, A. Antibacterial activity and chemical composition of the leaf essential oil of mentha rotundifolia from Morocco. Electronic journal of environmental, agricultural and food chemistry, 2010, vol. 9, no. 1, p. 19-28.
Shibata, Hisao., Shimizu, Sumio. Essential oil of Mentha rotundifolia. VII. Absolute configuration of 1,2-epoxy methyl acetate isolated from a new chemical strain of M. rotundifolia. Agricultural and Biological Chemistry, 1973, p. 2675-2676.
Mahmoud, I., Alkofahi, A., Abdelaziz, A. Mutagenic and toxic activities of several spices and some Jordanian medicinal plants. International journal of pharmacognosy, 1992, vol. 30, no. 2, p. 81-85.
Lazutka, JR., Mierauskiene, J., Slapsyte, G., Dedonyte, V. Genotoxicity of dill (Anethum graveolens L.), peppermint (Mentha x piperita L.) and pine (Pinus sylvestris L.) essential oils in human lymphocytes and Drosophila melanogaster . Food and chemical toxicology, 2001, vol. 39, no. 5, p. 485-492. DOI
Debbab, A., Mosaddak, B., Aly, A. H., Hakiki, A., Mosaddak, M. CHEMICAL CHARACTERIZATION AND TOXICOLOGICAL EVALUATION OF THE ESSENTIAL OIL OF MENTHA PIPERITA L. GROWING IN MOROCCO. Scientific study and research-chemistry and chemical engineering biotechnology food industry, 2007, vol. 8, no. 3, p. 281-288.
Final report on the safety assessment of Mentha Piperita (Peppermint) Oil, Mentha Piperita (Peppermint) Leaf Extract, Mentha Piperita (Peppermint) Leaf, and Mentha Piperita (Peppermint) Leaf Water. International journal of toxicology, 2001, vol. 20, p. 61-73.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature