Botanical species · safety record

Moringa oleifera

The EFSA Compendium of Botanicals holds 18 constituent measurements, 7 adverse-effect records and 1 genotoxicity assay for Moringa oleifera. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Moringa oleifera Lam.

18Constituent measurements

8Safety records

8Cited sources

549Licensed products (Canada)

Also recorded as

Moringa pterygosperma Gaertn.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 549 licensed products naming Moringa oleifera as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Fresh

Source material stated

Fruit
Leaf
Leaf extract
Moringa Oleifera
Moringa oleifera - Leaf
Moringa oleifera - Seed extract
New material
Seed

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI
Cardiac glycosides	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI
Cyanide	Seed	Solvent extraction	4.16 Percent	GC-FID-MS	Resolve DOI
Erucic acid	Seed	Essential oil	—	LC-MS/MS	Resolve DOI
Glucosinolates	Leaves	Solvent extraction	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Glucotropaeolin	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Isothiocyanates	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Phenethyl isothiocyanate	Leaves	Solvent extraction	80 Milligram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Saponins	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI
Tannins	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI
Alkaloids	Aerial part of plants	Solvent extraction	≤ 6.68 Percent	Unspecified	No resolvable identifier
Alkaloids	Aerial part of plants	Solvent extraction	≥ 0.53 Percent	Unspecified	No resolvable identifier
Cyanogenic glycosides	Aerial part of plants	Solvent extraction	≤ 7.4 Milligram/100 gram	Unspecified	No resolvable identifier
Cyanogenic glycosides	Aerial part of plants	Solvent extraction	≥ 6.5 Milligram/100 gram	Unspecified	No resolvable identifier
Oxalates	Aerial part of plants	Solvent extraction	≥ 17.172 Milligram/100 gram	Unspecified	No resolvable identifier
Oxalates	Aerial part of plants	Solvent extraction	≤ 31.98 Milligram/100 gram	Unspecified	No resolvable identifier
Saponins	Aerial part of plants	Solvent extraction	≥ 14.3 Percent	Unspecified	No resolvable identifier
Saponins	Aerial part of plants	Solvent extraction	≤ 35.66 Percent	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Cardiovascular / haematological	Seed	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Neurotoxicity	Respiratory	Seed	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Neurotoxicity	Respiratory	Seed	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Systemic	Neurologic	Seed	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Systemic	—	Seed	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Reproductive	Uterus	Bark	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier
Reproductive	Uterus	Bark	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	With and without	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Zade, Varsha., Dabhadkar, Dinesh. Antifertility effect of alcoholic extract of Moringa oleifera stem bark on estrous cycle and estrogenic activity of female albino rat. American journal of advanced drug delivery, 2015, vol. 3, no. 3, p. 223-235.
Ajibade, Temitayo Olabisi., Arowolo, Ruben., Olayemi, Funsho Olakitike. Phytochemical screening and toxicity studies on the methanol extract of the seeds of moringa oleifera.. Journal of complementary & integrative medicine, 2013, vol. 10. DOI
Rolim, Luciola A. D. M. M., Macedo, Marcia F. S., Sisenando, Herbert Ary., Napoleao, Thiago H., Felzenszwalb, Israel., Aiub, Claudia A. F., Coelho, Luana C. B. B., Medeiros, Silvia R. B., Paiva, Patricia M. G. Genotoxicity Evaluation of Moringa oleifera Seed Extract and Lectin. Journal of food science, 2011, vol. 76, no. 2, p. T53-T58. DOI
Oluwaniyi, O. O., Obi, B. C. Phytochemical, Anti-nutritional and Toxicity Assessment of Moringa Oleifera Seeds, Stem Bark and Leaves Using Brine Shrimp (Artemia Salina) Assay. Jordan journal of chemistry, 2018, vol. 13, no. 3, p. 171-178.
Atolani, O., Olorundare, O.E., Banerjee, P., Osin, O.A., Preissner, R., Njan, A.A. Isolation, characterisation and in silico toxicity evaluations of thiocarbamates, isothiocyanates, nitrile, glucosinolate and lipids from moringa oleifera lam. Seed. Journal of the turkish chemical society, section a: chemistry, 2020, vol. 7, no. 1, p. 235-244. DOI
Elsayed, E. A., Farooq, M., Sharaf-Eldin, M. A., El-Enshasy, H. A., Wadaan, M. Evaluation of developmental toxicity and anti-angiogenic potential of essential oils from Moringa oleifera and Moringa peregrina seeds in zebrafish (Danio rerio) model. South african journal of botany, 2020, vol. 129, p. 229-237. DOI
Foerster, Nadja., Mewis, Inga., Glatt, Hansruedi., Haack, Michael., Brigelius-Flohe, Regina., Schreiner, Monika., Ulrichs, Christian. Characteristic single glucosinolates from Moringa oleifera: Induction of detoxifying enzymes and lack of genotoxic activity in various model systems. Food & function, 2016, vol. 7, no. 11, p. 4660-4674. DOI
Murakami, A., Kitazono, Y., Jiwajinda, S., Koshimizu, K., Ohigashi, H. Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus activation. Planta medica, 1998, vol. 64, no. 4, p. 319-323. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature