Botanical species · safety record

Mucuna pruriens

The EFSA Compendium of Botanicals holds 19 constituent measurements and 8 adverse-effect records for Mucuna pruriens. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Mucuna pruriens (L.) DC.

19Constituent measurements

8Safety records

5Cited sources

199Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 199 licensed products naming Mucuna pruriens as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Bean
Fruit
Graine
Hairs of the fruit
Mucuna pruriens - Root
Mucuna pruriens - seed
New material
Root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	4 Percent	Phytochemical screening	Resolve DOI
Alkaloids	Leaves	Solvent extraction	0.35 Percent	Phytochemical screening	Resolve DOI
Anthraquinones	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Cardiac glycosides	Leaves	Solvent extraction	13.32 Percent	Phytochemical screening	Resolve DOI
Formononetin	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Hydrogen cyanide (cyanides expressed as hydrogen cyanide)	Leaves	Solvent extraction	0.675 Percent	Phytochemical screening	Resolve DOI
Isoflavones	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Isoflavonoids	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Medicarpin	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Oxalates	Leaves	Solvent extraction	0.168 Percent	Phytochemical screening	Resolve DOI
Pterocarpans	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Saponins	Leaves	Solvent extraction	5.06 Percent	Phytochemical screening	Resolve DOI
Saponins	Leaves	Solvent extraction	1 Percent	Phytochemical screening	Resolve DOI
Alkaloids	Seed	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Hydrogen cyanide (cyanides expressed as hydrogen cyanide)	Seed	Raw, no heat treatment	12.69 Milligram/kilogram	Phytochemical screening	No resolvable identifier
Hydrogen cyanide (cyanides expressed as hydrogen cyanide)	Seed	Thermal treatment (heating for preservation)	≥ 5.54 Milligram/kilogram	Phytochemical screening	No resolvable identifier
Hydrogen cyanide (cyanides expressed as hydrogen cyanide)	Seed	Thermal treatment (heating for preservation)	≤ 6.59 Milligram/kilogram	Phytochemical screening	No resolvable identifier
Saponins	Seed	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tannins	Seed	Solvent extraction	—	Phytochemical screening	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Roots and other underground parts	Solvent extraction	Saccharomyces cerevisiae (as organism)	In vitro	Resolve DOI
Digestive	Digestive	Roots and other underground parts	Solvent extraction	Saccharomyces cerevisiae (as organism)	In vitro	Resolve DOI
Digestive	Digestive	Roots and other underground parts	Solvent extraction	Saccharomyces cerevisiae (as organism)	In vitro	Resolve DOI
Hepatotoxicity	Liver	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Neurotoxicity	Brain	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Pulmonary and cardiac	Lung	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Reproductive	Testes	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Dendup, Tshewang., Prachyawarakorn, Vilailak., Pansanit, Acharavadee., Mahidol, Chulabhorn., Ruchirawat, Somsak., Kittakoop, Prasat. alpha-Glucosidase Inhibitory Activities of Isoflavanones, Isoflavones, and Pterocarpans from Mucuna pruriens . Planta medica, 2014, vol. 80, no. 7, p. 604-608. DOI
Nweze, N.E., Ezema, C., Ezema, A.S., Eze, J.I., Ezema, W.S. Toxicity and nutritional studies on Mucuna pruriens leaves from Nsukka, South-Eastern Nigeria. Comparative clinical pathology, 2017, vol. 26, no. 3, p. 569-574. DOI
Saikarthik, J., Vijayakumar, J., Vijayaraghavan, R. Qualitative phytochemistry and acute oral toxicity testing of the methanol extract of mucuna pruriens seeds in albino mice. International journal of pharmaceutical sciences review and research, 2016, vol. 38, no. 2, p. 198-204.
Minari, J.B., Ogar, G.O., Bello, A.J. Antiproliferative potential of aqueous leaf extract of Mucuna pruriens on DMBA-induced breast cancer in female albino rats. Egyptian journal of medical human genetics, 2016, vol. 17, no. 4, p. 331-343. DOI
Nwaoguikpe, R.N., Braide, W., Ujowundu, C.O. The effects of processing on the proximate and phytochemical compositions of mucuna pruriens seeds (Velvet beans). Pakistan journal of nutrition, 2011, vol. 10, no. 10, p. 947-951.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature