Botanical species · safety record

Nelumbo nucifera

The EFSA Compendium of Botanicals holds 13 constituent measurements and 4 adverse-effect records for Nelumbo nucifera. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Nelumbo nucifera Gaertn.

13Constituent measurements

4Safety records

8Cited sources

383Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 383 licensed products naming Nelumbo nucifera as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
solid

Source material stated

Flower
Flower receptacle
Fruit
Leaf
Leaf/Leaves
Lotus leaves
Nelumbo nucifera
New material

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Anonaine	Leaves	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Alkaloids	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Alkaloids	Fruit unspecified	Solvent extraction	—	IR and Raman Spectroscopy	No resolvable identifier
Alkaloids	Live plants	Solvent extraction	—	—	No resolvable identifier
Alkaloids	Aerial part of plants	Solvent extraction	—	IR and Raman Spectroscopy	No resolvable identifier
Alkaloids	Stem / stalk	Solvent extraction	—	Gaschromatography (GC)	No resolvable identifier
Isoquinoline alkaloids	Fruit unspecified	Solvent extraction	—	IR and Raman Spectroscopy	No resolvable identifier
Isoquinoline alkaloids	Seed	Solvent extraction	—	IR and Raman Spectroscopy	No resolvable identifier
Liriodenine	Seed	Solvent extraction	—	IR and Raman Spectroscopy	No resolvable identifier
Neferine	Seed	Solvent extraction	—	—	No resolvable identifier
Nornuciferine	Leaves	Solvent extraction	—	IR and Raman Spectroscopy	No resolvable identifier
Nornuciferine	Fruit unspecified	Solvent extraction	—	IR and Raman Spectroscopy	No resolvable identifier
Roemerine	Leaves	Solvent extraction	—	IR and Raman Spectroscopy	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive: pancreas	Leaves	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive: pancreas	Leaves	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive: pancreas	Leaves	Solvent extraction	—	In vitro	Resolve DOI
Reproductive	Urogenital	Seed	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Qian, JQ. Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives . Acta pharmacologica sinica, 2002, vol. 23, no. 12, p. 1086-1092.
Yang, Tsang-Hsiung., Chen, Chi-Ming., Lu, Chang-Sha., Liao, Chen-Long. Alkaloids of lotus receptacle. Journal of the Chinese Chemical Society (Taipei, Taiwan), 1972, p. 143-147.
Hu, Jiang-Ning., Shan, Bin., Deng, Ze-Yuan., Li, Jing., Fan, Ya-Wei., Ruan, Zheng., Liu, Rong. Application of High-speed Counter-current Chromatography for the Isolation of 5 Alkaloids from Lotus (Nelumbo nucifera Gaertn.) Leaves. FOOD SCIENCE AND BIOTECHNOLOGY, 2010, vol. 19, no. 6, p. 1661-1665. DOI
Yan, Ming-Zhu., Chang, Qi., Zhong, Yu., Xiao, Bing-Xin., Feng, Li., Cao, Fang-Rui., Pan, Rei-Le., Zhang, Ze-Sheng., Liao, Yong-Hong., Liu, Xin-Min. Lotus Leaf Alkaloid Extract Displays Sedative-Hypnotic and Anxiolytic Effects through GABAA Receptor. Journal of agricultural and food chemistry, 2015.
Liu, Song., Li, Dong., Huang, Bo., Chen, Yuxin., Lu, Xiaocong., Wang, Youwei. Inhibition of pancreatic lipase, alpha-glucosidase, alpha-amylase, and hypolipidemic effects of the total flavonoids from Nelumbo nucifera leaves . Journal of ethnopharmacology, 2013, vol. 149, no. 1, p. 263-269. DOI
Mutreja, Anju., Agarwal, Meera., Kushwaha, Sonalika., Chauhan, Alka. Effect of Nelumbo nucifera seeds on the reproductive organs of female rats . Iranian journal of reproductive medicine, 2008, vol. 6, no. 1, p. 7-11.
Canonica, Luigi., Nali, Micaela., Rindone, Bruno., Tollari, Stefano., Marchesini, Augusto. Biomimetic oxidations of benzylisoquinoline alkaloids. I. The peroxidase and ascorbic oxidase-catalyzed oxidation. Gazzetta chimica italiana, 1985, p. 1-5.
Duan, Xu-Hong., Pei, Lin., Jiang, Jian-Qin. Cytotoxic alkaloids from stems of Nelumbo nucifera .. Zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2013, vol. 38, no. 23, p. 4104-8.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature