Botanical species · safety record

Nerium oleander

The EFSA Compendium of Botanicals holds 6 constituent measurements and 13 adverse-effect records for Nerium oleander. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Nerium oleander L.

6Constituent measurements

13Safety records

12Cited sources

5Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 5 licensed products naming Nerium oleander as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Fresh leaf
Fresh leaves collected before the start of flowering
Leaf/Leaves

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Cardiac glycosides	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Cardiac glycosides	Leaves	Solvent extraction	0.0402 Gram	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Oleandrin	Leaves	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Cardiac glycosides	Unspecified	—	—	—	No resolvable identifier
Digitoxigenin	Unspecified	—	—	—	No resolvable identifier
Oleandrin	Unspecified	—	—	—	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Neurologic: central nervous system	Leaves	Solvent extraction	Human (as organism)	Case report	Resolve DOI
Digestive	Neurologic: central nervous system	Leaves	—	Dog (as animal)	Acute toxicity	Resolve DOI
Digestive	Neurologic: central nervous system	Seed	—	Cattle (as animal)	Case report	Resolve DOI
Digestive	Heart	Leaves	Solvent extraction	Human (as organism)	Case report	Resolve DOI
Hepatotoxicity	Urogenital: kidneys	Aerial part of plants	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Hepatotoxicity	Urogenital: kidneys	Aerial part of plants	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI
Neurotoxicity	Neurologic: central nervous system	Flower	—	Human (as organism)	Case report	Resolve DOI
Systemic	Neurologic: central nervous system	Aerial part of plants	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Systemic	Neurologic: central nervous system	Aerial part of plants	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Digestive	Cardiovascular / haematological	Leaves	—	Human (as organism)	Case report	No resolvable identifier
Nephrotoxicity	Digestive	Aerial part of plants	—	Animals (as animal)	Case report	No resolvable identifier
Pulmonary and cardiac	Heart	Leaves	—	—	Case report	No resolvable identifier
Pulmonary and cardiac	Heart	Leaves	—	—	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Khan, Ibraheem., Kant, Chandra., Sanwaria, Anil., Meena, Lokesh. Acute cardiac toxicity of nerium oleander/indicum poisoning (kaner) poisoning. . Heart views : the official journal of the gulf heart association, 2010, vol. 11, no. 3, p. 115-6. DOI
Camplesi, Annelise Carla., Bellodi, Carolina., Mesa Socha, Jose Javier., Hatayde, Mario Roberto., da Rosa Sobreira, Marcia Ferreira., Marques Araujo, Gustavo Henrique., Moya Araujo, Carla Fredrichsen. Dogs poisoned with Nerium oleander fresh leaves: clinical and electrocardiographic findings . Ciencia rural, 2017, vol. 47, no. 6. DOI
Wasfi, Ibrahim A., Zorob, Omar., Al Katheeri, Nawal A., Al Awadhi, Anwar M. A fatal case of oleandrin poisoning. Forensic science international, 2008, vol. 179(2-3), p. e31-e36.
Pedroso, Pedro M. O., Bandarra, Paulo M., Bezerra Junior, Pedro S., Raymundo, Djeison L., Borba, Mauro R., Leal, Juliano S., Driemeier, David. Natural and experimental poisoning by Nerium oleander (Apocynaceae) in cattle in Rio Grande do Sul . Pesquisa veterinaria brasileira, 2009, vol. 29, no. 5, p. 404-408.
Soto-Blanco, B., Fontenele-Neto, J. D., Silva, D. M., Reis, P. F. C. C., Nobrega, J. E. Acute cattle intoxication from Nerium oleander pods. Tropical animal health and production, 2006, vol. 38, no. 6, p. 451-454. DOI
Bavunoglu, Isil., Balta, Musa., Turkmen, Zeynep. Oleander Poisoning as an Example of Self-Medication Attempt. Balkan medical journal, 2016, vol. 33, no. 5, p. 559-562. DOI
Khordadmehr, Monire., Nazifi, Saeed., Mansourian, Maryam., Basiri, Sara., Kolahian, Saeed. Experimental Nerium oleander poisoning in Balb/c mice and Wistar rat: comparative hepatotoxicity and nephrotoxicity effects based on biochemical and pathological studies . Turkish journal of biochemistry-turk biyokimya dergisi, 2017, vol. 42, no. 4, p. 427-434. DOI
Pietsch, J., Oertel, R., Trautmann, S., Schulz, K., Kopp, B., Dressler, J. A non-fatal oleander poisoning. International journal of legal medicine, 2005, vol. 119, no. 4, p. 236-240. DOI
Kozikowski, Tania A., Magdesian, K. Gary., Puschner, Birgit. Oleander intoxication in New World camelids: 12 cases (1995-2006). Javma-journal of the american veterinary medical association, 2009, vol. 235, no. 3, p. 305-310.
Dai, Lingpeng., Wang, Wanxian., Dong, Xinjiao., Hu, Renyong., Nan, Xuyang. Molluscicidal activity of cardiac glycosides from Nerium indicum against Pomacea canaliculata and its implications for the mechanisms of toxicity . Environmental toxicology and pharmacology, 2011, vol. 32, no. 2, p. 226-232. DOI
Roberts, Darren M., Gallapatthy, Gamini., Dunuwille, Asunga., Chan, Betty S. Pharmacological treatment of cardiac glycoside poisoning. British journal of clinical pharmacology, 2016, vol. 81, no. 3, p. 488-495.
Turkmen, Zeynep., Mercan, Selda., Cengiz, Salih. An HPTLC Method for the Determination of Oleandrin in Nerium Plant Extracts and Its Application to Forensic Toxicology . Jpc-journal of planar chromatography-modern tlc, 2013, vol. 26, no. 3, p. 279-283. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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