Botanical species · safety record

Nicotiana tabacum

The EFSA Compendium of Botanicals holds 5 constituent measurements and 1 genotoxicity assay for Nicotiana tabacum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Nicotiana tabacum L.

5Constituent measurements

1Safety records

2Cited sources

10Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 10 licensed products naming Nicotiana tabacum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Dried unfermented leaves
Leaf
Leaf/Leaves

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Anthraquinones	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Cardiac glycosides	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Coumarins	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Tannins	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	micronucleus assay	Human (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

da Silva, Fernanda R., Erdtmann, Bernardo., Dalpiaz, Tiago., Nunes, Emilene., Ferraz, Alexandre., Martins, Tales L. C., Dias, Johny F., da Rosa, Darlan P., Porawskie, Marilene., Bona, Silvia., da Silva, Juliana. Genotoxicity of Nicotiana tabacum leaves on Helix aspersa. Genetics and molecular biology, 2013, vol. 36, no. 2, p. 269-275. DOI
Rana, S.V.S., Verma, Y., Singh, G.D. Assessment of genotoxicity amongst smokers, alcoholics, and tobacco chewers of North India using micronucleus assay and urinary 8-hydroxyl-2'-deoxyguanosine, as biomarkers. Environmental monitoring and assessment, 2017, vol. 189, no. 8. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature