Botanical species · safety record

Nigella sativa

The EFSA Compendium of Botanicals holds 1 constituent measurement, 1 adverse-effect record and 1 genotoxicity assay for Nigella sativa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Nigella sativa L.

1Constituent measurements

2Safety records

3Cited sources

232Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 232 licensed products naming Nigella sativa as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Grain
Leaf
New material
Seed
Seed oil
Seed oleoresin
Seed(s)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Thymoquinone	Seed	Essential oil	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Stomach	Seed	Solvent extraction	Rat (as animal)	Acute toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	—	bacterial gene mutation assay	Salmonella typhimurium (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Khalil, W.K.B., Abdel-Gawad, F.K.H., Belattar, N., Senator, A., Abdel-Wahhab, M.A. Protective effects of Nigella sativa extract against chromiumvi-induced genotoxicity in Nile Tilapia (Oreochromis niloticus) and zebrafish (Danio rerio). Global veterinaria, 2011, vol. 7, no. 3, p. 283-293.
Vahdati-Mashhadian, N., Rakhshandeh, H., Omidi, A. An investigation on LD50 and subacute hepatic toxicity of Nigella sativa seed extracts in mice . Pharmazie, 2005, vol. 60, no. 7, p. 544-547.
Mahmoud, I., Alkofahi, A., Abdelaziz, A. Mutagenic and toxic activities of several spices and some jordanian medicinal plants. Pharmaceutical biology, 1992, vol. 30, no. 2, p. 81-85. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature