Botanical species · safety record

Pachyrhizus erosus

The EFSA Compendium of Botanicals holds 12 constituent measurements, 2 adverse-effect records and 1 genotoxicity assay for Pachyrhizus erosus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Pachyrhizus erosus (L.) Urb.

12Constituent measurements

3Safety records

8Cited sources

1Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1 licensed products naming Pachyrhizus erosus as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Isoflavones	Seed	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Pachyrrhizin	Seed	Solvent extraction	≥ 0.25 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Pachyrrhizin	Seed	Solvent extraction	≤ 3.29 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Rotenone	Seed	Solvent extraction	≥ 1.13 Milligram/gram	HPLC-UV	Resolve DOI
Rotenone	Seed	Solvent extraction	≥ 0.58 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Rotenone	Seed	Solvent extraction	≤ 3.53 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Rotenone	Seed	Solvent extraction	≤ 2.76 Milligram/gram	HPLC-UV	Resolve DOI
Abrin	Roots and other underground parts used as staple food	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Daidzin	Roots and other underground parts used as staple food	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Furanocoumarins	Seed	Solvent extraction	—	Unspecified	No resolvable identifier
Pentacyclic triterpene saponins	Roots and other underground parts used as staple food	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Rotenoids	Seed	Solvent extraction	—	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	Digestive	Seed	—	—	Case report	No resolvable identifier
Systemic	—	Seed	—	Human (as organism)	Case report	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro	Human (as organism)	No data	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Lautie, E., Rozet, E., Hubert, P., Leclercq, J. Quetin. Quantification of rotenone in seeds of different species of yam bean (Pachyrhizus sp.) by a SPE HPLC-UV method. FOOD CHEMISTRY, 2012, vol. 131, no. 4, p. 1531-1538. DOI
Lautie, E., Rozet, E., Hubert, P., Vandelaer, N., Billard, F., Zum Felde, T., Grueneberg, W. J., Quetin-Leclercq, J. Fast method for the simultaneous quantification of toxic polyphenols applied to the selection of genotypes of yam bean (Pachyrhizus sp.) seeds. TALANTA, 2013, vol. 117, p. 94-101. DOI
Estrella-Parra, Edgar A., Gomez-Verjan, Juan C., Gonzalez-Sanchez, Ignacio., Ricardo Vazquez-Martinez, Edgar., Vergara-Castaneda, Edgar., Cerbon, Marco A., Alavez-Solano, Dagoberto., Reyes-Chilpa, Ricardo. Rotenone isolated from Pachyrhizus erosus displays cytotoxicity and genotoxicity in K562 cells. NATURAL PRODUCT RESEARCH, 2014, vol. 28, no. 20, p. 1780-1785. DOI
Krishnamurti, M., Seshadri, T. R. Chemical components of yam beans; their evolution and interrelation. Current science, 1966, p. 167-169.
Yahara, Shoji., Irino, Nobuto., Takaoka, Tsuneo., Nohara, Toshihiro. Studies on the constituents of Pachyrhizus erosus. Natural Medicines, 1994, vol. 48, no. 4, p. 312-313.
Baker, Bella Y., Lynn, E. V. Examination of the seed of Pachyrrhizus erosus. Journal of the american pharmaceutical association, None, p. 117-118.
Narongchai, Paitoon., Narongchai, Siripun., Thampituk, Suparat. The first fatal case of yam bean and rotenone toxicity in Thailand. Journal of the Medical Association of Thailand, 2005, vol. 88, no. 7, p. 984-987.
Hung, Y.-M., Hung, S.-Y., Olson, K. R., Chou, K.-J., Lin, S.-L., Chung, H.-M., Tung, C.-N., Chang, J.-C. Yam bean seed poisoning mimicking cyanide intoxication. Internal Medicine Journal, 2007, p. 130-132.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature