Botanical species · safety record

Paris polyphylla

The EFSA Compendium of Botanicals holds 4 constituent measurements and 3 adverse-effect records for Paris polyphylla. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Paris polyphylla Sm.

4Constituent measurements

3Safety records

4Cited sources

17Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 17 licensed products naming Paris polyphylla as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Dried rhizome
Herb top
Rhizome
Whole plant(s)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Dioscin	Roots and other underground parts	Solvent extraction	5.16 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Gracillin	Roots and other underground parts	Solvent extraction	2.99 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Gracillin	Roots and other underground parts	Solvent extraction	≥ 0.16 Milligram/gram	HPLC with standard detection methods	No resolvable identifier
Gracillin	Roots and other underground parts	Solvent extraction	≤ 3.26 Milligram/gram	HPLC with standard detection methods	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Roots and other underground parts	—	Rat (as animal)	Subchronic	Resolve DOI
Pulmonary and cardiac	Lung	Roots and other underground parts	—	Rat (as animal)	Subchronic	Resolve DOI
Systemic	—	Roots and other underground parts	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Man, Shuli., Li, Jing., Liu, Jing., Chai, Hongyan., Liu, Zhen., Wang, Jiaming., Gao, Wenyuan. Curcumin alleviated the toxic reaction of Rhizoma Paridis saponins in a 45-day subchronic toxicological assessment of rats. . Environmental toxicology, 2015. DOI
Li, Yu., Gu, Jun-Fei., Zou, Xi., Wu, Jian., Zhang, Ming-Hua., Jiang, Jun., Qin, Dong., Zhou, Jin-Yong., Liu, Bao-Xin-Zi., Zhu, Yun-Tao., Jia, Xiao-Bin., Feng, Liang., Wang, Rui-Ping. The Anti-Lung Cancer Activities of Steroidal Saponins of P. polyphylla Smith var. chinensis (Franch.) Hara through Enhanced Immunostimulation in Experimental Lewis Tumor-Bearing C57BL/6 Mice and Induction of Apoptosis in the A549 Cell Line. MOLECULES, 2013, vol. 18, no. 10, p. 12916-12936. DOI
Man, Shuli., Gao, Wenyuan., Zhang, Yanjun., Wang, Jieyin., Zhao, Wanshun., Huang, Luqi., Liu, Changxiao. Qualitative and quantitative determination of major saponins in Paris and Trillium by HPLC-ELSD and HPLC-MS/MS. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2010, p. 2943-2948.
Liu, Zhen., Gao, Wenyuan., Man, Shuli., Wang, Jieyin., Li, Nan., Yin, Shuangshuang., Wu, Shanshan., Liu, Changxiao. Pharmacological evaluation of sedative-hypnotic activity and gastro-intestinal toxicity of Rhizoma Paridis saponins. JOURNAL OF ETHNOPHARMACOLOGY, 2012, vol. 144, no. 1, p. 67-72. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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