Botanical species · safety record

Parthenium hysterophorus

The EFSA Compendium of Botanicals holds 6 constituent measurements, 2 adverse-effect records and 1 genotoxicity assay for Parthenium hysterophorus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Parthenium hysterophorus L.

6Constituent measurements

3Safety records

6Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Aerial part of plants	Solvent extraction	—	Phytochemical screening	Resolve DOI
Parthenin	Unspecified	—	—	Unspecified	Resolve DOI
Sesquiterpene lactones	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Tannins	Aerial part of plants	Solvent extraction	—	Phytochemical screening	Resolve DOI
Myrcene	Leaves	Essential oil	3.23 Percent	GC-MS	No resolvable identifier
Saponins	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Aerial part of plants	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Systemic	Digestive	Aerial part of plants	—	Cattle (as animal)	Short-term toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	chromosome aberration assay	Human (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Narasimhan T R., Ananth M., Swamy M N., Babu M R., Mangala A., Rao P V. Toxicity of Parthenium hysterophorus L. to cattle and buffaloes. Experientia, 1977, p. 1358-1359.
Ramos, A., Rivero, R., Victoria, MC., Visozo, A., Piloto, J., Garcia, A. Assessment of mutagenicity in Parthenium hysterophorus L.. Journal of ethnopharmacology, 2001, vol. 77, no. 1, p. 25-30. DOI
Kushwaha, Veena B., Maurya, Shivani. Toxic effect of ethanolic extract of Parthenium hysterophorus on mammalian blood biochemistry. Journal of environment and bio-sciences, 2011, p. 155-160.
Chowdhury, A. R. Chemical examination of essential oil from Parthenium hysterophorus L. leaves. Indian perfumer, 2002, p. 45-48.
Ramos, A., Rivero, R., Visozo, A., Piloto, J., Garcia, A. Parthenin, a sesquiterpene lactone of Parthenium hysterophorus L. is a high toxicity clastogen . Mutation research-genetic toxicology and environmental mutagenesis, 2002, vol. 514, no. 1-2, p. 19-27. DOI
Pandey, Anjali., Rizvi, Masood., Shah, Bhahwal Ali., Bani, Sarang. Anti-arthritogenic effect of Saponin-1 by alteration of Th1/Th2 cytokine paradigm in arthritic mice. Cytokine+, 2016, p. 103-113.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature