Botanical species · safety record

Pausinystalia johimbe

The EFSA Compendium of Botanicals holds 43 constituent measurements and 3 adverse-effect records for Pausinystalia johimbe. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Pausinystalia johimbe (K.Schum.) Pierre ex Beille

43Constituent measurements

3Safety records

7Cited sources

1Licensed products (Canada)

Also recorded as

Corynanthe johimbe K.Schum.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1 licensed products naming Pausinystalia johimbe as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Ajmalicine	Bark	Solvent extraction	2.16 Percent	GC-MS	Resolve DOI
Ajmalicine	Bark	Solvent extraction	≥ 1.6 Percent	LC-MS	Resolve DOI
Ajmalicine	Bark	Solvent extraction	≤ 2.4 Percent	LC-MS	Resolve DOI
Alkaloids	Bark	Solvent extraction	3.74 Percent	GC-MS	Resolve DOI
Alkaloids	Bark	Solvent extraction	3.02 Percent	GC-MS	Resolve DOI
Alkaloids	Bark	Solvent extraction	0.37 Percent	GC-MS	Resolve DOI
Alkaloids	Bark	Solvent extraction	0.93 Percent	GC-MS	Resolve DOI
Alkaloids	Bark	Solvent extraction	1.92 Percent	GC-MS	Resolve DOI
Alkaloids	Bark	Solvent extraction	1.11 Percent	GC-MS	Resolve DOI
Beta-yohimbine	Bark	Solvent extraction	9.33 Percent	GC-MS	Resolve DOI
Corynanthine	Bark	Solvent extraction	0.3 Percent	GC-MS	Resolve DOI
Yohimbine	Bark	Solvent extraction	≥ 0.3 Percent	LC-MS	Resolve DOI
Yohimbine	Bark	Solvent extraction	62.26 Percent	GC-MS	Resolve DOI
Yohimbine	Bark	Solvent extraction	≤ 1.1 Percent	LC-MS	Resolve DOI
Yohimbine	Bark	Solvent extraction	8.61 Percent	GC-MS	Resolve DOI
Yohimbine	Bark	Solvent extraction	6.24 Percent	GC-MS	Resolve DOI
Alkaloids	Bark	—	0.4 Milligram/gram	Unspecified	No resolvable identifier
Alloyohimbine	Bark	Solvent extraction	—	HPLC hypenated to element spectrometry	No resolvable identifier
Alpha-yohimbine	Bark	—	≤ 0.46 Percent	Unspecified	No resolvable identifier
Alpha-yohimbine	Bark	—	≥ 0.39 Percent	Unspecified	No resolvable identifier
Alpha-yohimbine	Bark	Solvent extraction	—	HPLC hypenated to element spectrometry	No resolvable identifier
Anthraquinone	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Beta-yohimbine	Bark	—	0.03 Percent	Unspecified	No resolvable identifier
Beta-yohimbine	Bark	Solvent extraction	—	HPLC hypenated to element spectrometry	No resolvable identifier
Corynanthine	Bark	Solvent extraction	—	HPLC hypenated to element spectrometry	No resolvable identifier
Coumarins	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Indole alkaloids	Bark	—	≤ 150 Milligram/gram	Unspecified	No resolvable identifier
Indole alkaloids	Bark	Solvent extraction	—	HPLC hypenated to element spectrometry	No resolvable identifier
Indole alkaloids	Bark	—	≥ 2 Milligram/gram	Unspecified	No resolvable identifier
Phlobotannins	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Pseudoyohimbine	Bark	Solvent extraction	—	HPLC hypenated to element spectrometry	No resolvable identifier
Pseudoyohimbine	Bark	—	≥ 0.02 Percent	Unspecified	No resolvable identifier
Pseudoyohimbine	Bark	—	≤ 0.36 Percent	Unspecified	No resolvable identifier
Saponins	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tannins	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Yohimbine	Bark	Solvent extraction	—	HPLC hypenated to element spectrometry	No resolvable identifier
Yohimbine	Bark	—	10 Milligram/gram	Unspecified	No resolvable identifier
Yohimbine	Bark	—	≥ 0.8 Percent	Unspecified	No resolvable identifier
Yohimbine	Bark	—	≤ 2.24 Percent	Unspecified	No resolvable identifier
Yohimbine	Bark	Solvent extraction	—	HPLC hypenated to element spectrometry	No resolvable identifier

40 of 43 records are shown, ordered so that records carrying a resolvable reference come first.

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	Neurologic	Bark	—	Human (as organism)	Case report	No resolvable identifier
Systemic	—	Bark	—	Human (as organism)	Case report	No resolvable identifier
Systemic	Heart	Bark	—	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Lucas, Derick., Neal-Kababick, James., Zweigenbaum, Jerry. Characterization and Quantitation of Yohimbine and Its Analogs in Botanicals and Dietary Supplements Using LC/QTOF-MS and LC/QQQ-MS for Determination of the Presence of Bark Extract and Yohimbine Adulteration . Journal of aoac international, 2015, vol. 98, no. 2, p. 330-335. DOI
Cotten, Steven W., Hammett-Stabler, Catherine A. Risk of toxicity associated with unregulated herbal products. Herbal supplements, 2011, p. 45-72.
Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). Efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp.
Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . Journal of separation science, 2008, vol. 31, no. 12, p. 2211-2218. DOI
Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. Rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591-2602.
Sodipo, Oluwole A., Akinniyi, John A., Ogunbameru, Josephine V. Studies on certain characteristics of extracts of bark of Pausinystalia johimbe and Pausinystalia macroceras (K.Schum.) Pierre ex Beille. Global journal of pure and applied sciences, 2000, vol. 6, no. 1, p. 83-87.
Zanolari, Boris., Ndjoko, Karine., Ioset, Jean-Robert., Marston, Andrew., Hostettmann, Kurt. Qualitative and quantitative determination of yohimbine in authentic yohimbe bark and in commercial aphrodisiacs by HPLC-UV-API/MS methods. Phytochemical analysis, 2003, vol. 14, no. 4, p. 193-201.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature