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Botanical species · safety record

Perilla frutescens

The EFSA Compendium of Botanicals holds 2 constituent measurements and 1 adverse-effect record for Perilla frutescens. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Perilla frutescens (L.) Britton

2Constituent measurements
1Safety records
3Cited sources
506Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 506 licensed products naming Perilla frutescens as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

  • Dry
  • Extract Type TBA
  • solid

Source material stated

  • Aerial parts
  • Dried leaf
  • Dried ripe fruit (stir-baked)
  • Essential oil from leaf
  • Folium
  • Fruit
  • Fruit (fried)
  • Fruit (stir-baked)

What the records describe

Constituents measured

  • Myristicin1
  • Neolignans1

Plant parts

  • Leaves2
  • Seed1

Preparations

  • Solvent extraction2
  • Fresh1

Effect types

  • Pulmonary and cardiac1

Target tissues

  • Lung1

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
MyristicinLeavesSolvent extraction—High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
NeolignansLeavesSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

EffectTarget tissuePlant partPreparationTest organismTest typeSource
Pulmonary and cardiacLungSeedFreshCattle (as animal)Case reportNo resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Ryu, JH., Son, HJ., Lee, SH., Sohn, DH. Two neolignans from Perilla frutescens and their inhibition of nitric oxide synthase and tumor necrosis factor-alpha expression in murine macrophage cell line RAW 264.7 . Bioorganic & medicinal chemistry letters, 2002, vol. 12, no. 4, p. 649-651. DOI
  2. Lee, Hyun Jae., Lee, Kang Ro., Hong, Jang-Hee., Lee, Choong Jae. Effects of Caffeic Acid, Myristicin and Rosemarinic Acid on the Gene Expression and Production of Airway MUC5AC Mucin . Natural product sciences, 2016, vol. 22, no. 4, p. 275-281. DOI
  3. KERR, LA., JOHNSON, BJ., BURROWS, GE. INTOXICATION OF CATTLE BY PERILLA FRUTESCENS (PURPLE MINT). Veterinary and human toxicology, 1986, vol. 28, no. 5, p. 412-416.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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