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Botanical species · safety record

Petasites frigidus

The EFSA Compendium of Botanicals holds 6 constituent measurements for Petasites frigidus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Petasites frigidus (L.) Fr.

6Constituent measurements
0Safety records
2Cited sources
0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

  • Integerrimine1
  • Pyrrolizidine alkaloids1
  • Senecionine1
  • Senecionine-n-oxide1
  • Senkirkine1
  • Sesquiterpene lactones1

Plant parts

  • Roots and other underground parts6

Preparations

  • Solvent extraction4

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
IntegerrimineRoots and other underground partsSolvent extraction20 Nanogram/gramHPLC with standard detection methodsNo resolvable identifier
Pyrrolizidine alkaloidsRoots and other underground parts——High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
SenecionineRoots and other underground partsSolvent extraction120 Nanogram/gramHPLC with standard detection methodsNo resolvable identifier
Senecionine-n-oxideRoots and other underground partsSolvent extraction260 Nanogram/gramHPLC with standard detection methodsNo resolvable identifier
SenkirkineRoots and other underground partsSolvent extraction3000 Nanogram/gramHPLC with standard detection methodsNo resolvable identifier
Sesquiterpene lactonesRoots and other underground parts—0.01 PercentHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Avula, Bharathi., Sagi, Satyanarayanaraju., Wang, Yan-Hong., Zweigenbaum, Jerry., Wang, Mei., Khan, Ikhlas A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. Food Chemistry, 2015, p. 136-148.
  2. Avula, Bharathi., Wang, Yan-Hong., Wang, Mei., Smillie, Troy J., Khan, Ikhlas A. Simultaneous determination of sesquiterpenes and pyrrolizidine alkaloids from the rhizomes of Petasites hybridus (L.) G.M. et Sch. and dietary supplements using UPLC-UV and HPLC-TOF-MS methods. Journal of Pharmaceutical and Biomedical Analysis, 2012, p. 53-63.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature

Europe PMC

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In its own terms

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How the living traditions approach preparation, use and context.