Botanical species · safety record

Petasites hybridus

The EFSA Compendium of Botanicals holds 39 constituent measurements for Petasites hybridus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Petasites hybridus (L.) G.Gaertn., B.Mey. & Scherb.

39Constituent measurements

0Safety records

12Cited sources

32Licensed products (Canada)

Also recorded as

Petasites officinalis Moench

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 32 licensed products naming Petasites hybridus as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Leaf
Petasites hybridus - Root
Rhizome
Rhizome (standardized extract)
Rhizome and root(s)
Root
Root and Rhizome
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Integerrimine	Live plants	Solvent extraction	12.4 Microgram/gram	Gaschromatography (GC)	Resolve DOI
Integerrimine	Roots and other underground parts	Solvent extraction	≥ 70.4 Nanogram/gram	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Integerrimine	Roots and other underground parts	Solvent extraction	≤ 80.6 Nanogram/gram	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Petasitenine	Roots and other underground parts	Solvent extraction	—	HPLC-UV	Resolve DOI
Pyrrolizidine alkaloids	Roots and other underground parts	Solvent extraction	≤ 90 ppm	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Pyrrolizidine alkaloids	Roots and other underground parts	Solvent extraction	0.008 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Pyrrolizidine alkaloids	Roots and other underground parts	Solvent extraction	≥ 2 Milligram/kilogram	Gaschromatography (GC)	Resolve DOI
Pyrrolizidine alkaloids	Roots and other underground parts	Solvent extraction	≤ 191 Milligram/kilogram	Gaschromatography (GC)	Resolve DOI
Pyrrolizidine alkaloids	Roots and other underground parts	Solvent extraction	—	HPLC-UV	Resolve DOI
Pyrrolizidine alkaloids	Live plants	Solvent extraction	≥ 18 Milligram/kilogram	Enzyme Immunoassay Tests (EIA)	Resolve DOI
Pyrrolizidine alkaloids	Live plants	Solvent extraction	≤ 255 Milligram/kilogram	Enzyme Immunoassay Tests (EIA)	Resolve DOI
Pyrrolizidine alkaloids	Leaves	Solvent extraction	≥ 0.02 ppm	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Pyrrolizidine alkaloids	Leaves	Solvent extraction	≤ 1.5 ppm	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Pyrrolizidine alkaloids	Roots and other underground parts	Solvent extraction	≥ 5 ppm	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Senecionine	Leaves	Super-critical gas extraction	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Senecionine	Leaves	Solvent extraction	3.86 ppm	Immunological detection or quantification method	Resolve DOI
Senecionine	Live plants	Solvent extraction	104 Microgram/gram	Gaschromatography (GC)	Resolve DOI
Senecionine	Roots and other underground parts	Solvent extraction	104.8 ppm	Immunological detection or quantification method	Resolve DOI
Senecionine	Roots and other underground parts	Solvent extraction	≥ 259.4 Nanogram/gram	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Senecionine	Roots and other underground parts	Solvent extraction	≤ 260.6 Nanogram/gram	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Senecionine-n-oxide	Leaves	Super-critical gas extraction	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Senecionine-n-oxide	Roots and other underground parts	Solvent extraction	800 Nanogram/gram	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Seneciphylline-n-oxide	Leaves	Super-critical gas extraction	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Senkirkine	Leaves	Super-critical gas extraction	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Senkirkine	Roots and other underground parts	Solvent extraction	≥ 999.6 Nanogram/gram	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Senkirkine	Roots and other underground parts	Solvent extraction	≤ 1000.4 Nanogram/gram	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Sesquiterpene lactones	Roots and other underground parts	Solvent extraction	≤ 15.3 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Sesquiterpene lactones	Roots and other underground parts	Solvent extraction	0.03 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Sesquiterpene lactones	Leaves	Solvent extraction	≥ 3.3 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Sesquiterpene lactones	Leaves	Solvent extraction	≤ 11.4 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Sesquiterpene lactones	Roots and other underground parts	Solvent extraction	0.06 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Sesquiterpene lactones	Roots and other underground parts	Solvent extraction	≥ 7.4 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Sesquiterpene lactones	Roots and other underground parts	Solvent extraction	0.01 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Sesquiterpene lactones	Roots and other underground parts	Solvent extraction	0.11 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Sesquiterpene lactones	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Benzofurans	Roots and other underground parts	—	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Pyrrolizidine alkaloids	Aerial part of plants	—	0.45 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Senecionine	Live plants	Solvent extraction	11.3 ppm	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Senkirkine	Live plants	Solvent extraction	25.8 ppm	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Wildi, E., Langer, T., Schaffner, W., Buter, KB. Quantitative analysis of petasin and pyrrolizidine alkaloids in leaves and rhizomes of in situ grown Petasites hybridus plants . Planta medica, 1998, vol. 64, no. 3, p. 264-267. DOI
Avula, Bharathi., Wang, Yan-Hong., Wang, Mei., Smillie, Troy J., Khan, Ikhlas A. Simultaneous determination of sesquiterpenes and pyrrolizidine alkaloids from the rhizomes of Petasites hybridus (L.) GM et Sch and dietary supplements using UPLC-UV and HPLC-TOF-MS methods . Journal of pharmaceutical and biomedical analysis, 2012, vol. 70, p. 53-63. DOI
Chizzola, R., Ozelsberger, B., Langer, T. Variability in chemical constituents in Petasites hybridus from Austria. Biochemical systematics and ecology, 2000, vol. 28, no. 5, p. 421-432. DOI
Aydin, Ahmet Alper., Letzel, Thomas. Simultaneous investigation of sesquiterpenes, pyrrolizidine alkaloids and N-oxides in Butterbur (Petasites hybridus) with an offline 2D-combination of HPLC-UV and LC-MMI-ToF-MS . Journal of pharmaceutical and biomedical analysis, 2013, vol. 85, p. 74-82. DOI
Pank, F., Vender, C., Van Niekerk, L., Junghanns, W., Langbehn, J., Bl�thner, W.-D., Novak, J., Franz, C. Distribution of pyrrolizidine alkaloids in crossing progenies of Petasites hybridus. Journal of herbs, spices and medicinal plants, 2002, vol. 9, no. 2-3, p. 39-44. DOI
Rostami-Charati, Faramarz., Hossaini, Zinatossadat., Khalilzadeh, Mohammad A. Novel Isocyanide-Based Three-Component Synthesis of Substituted 9H-furo 2,3-f chromene-8,9-Dicarboxylates in Water . Combinatorial chemistry & high throughput screening, 2012, vol. 15, no. 5, p. 433-437.
CHIZZOLA, R. RAPID SAMPLE PREPARATION TECHNIQUE FOR THE DETERMINATION OF PYRROLIZIDINE ALKALOIDS IN PLANT-EXTRACTS . Journal of chromatography a, 1994, vol. 668, no. 2, p. 427-433. DOI
Avula, Bharathi., Sagi, Satyanarayanaraju., Wang, Yan-Hong., Zweigenbaum, Jerry., Wang, Mei., Khan, Ikhlas A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry . Food chemistry, 2015, vol. 178, p. 136-148. DOI
Schenk, Alexander., Siewert, Beate., Toff, Stephan., Drewe, Juergen. UPLC TOF MS for sensitive quantification of naturally occurring pyrrolizidine alkaloids in Petasites hybridus extract (Ze 339) . Journal of chromatography b-analytical technologies in the biomedical and life sciences, 2015, vol. 997, p. 23-29. DOI
Sener, Bilge., Ergun, Fatma. Pyrrolizidine alkaloids from Petasites hybridus (L.) Gaertner. Journal of faculty of pharmacy of gazi university, 1996, vol. 13, no. 2, p. 171-173.
Langer, T., Mostl, E., Chizzola, R., Gutleb, R. A competitive enzyme immunoassay for the pyrrolizidine alkaloids of the senecionine type . Planta medica, 1996, vol. 62, no. 3, p. 267-271. DOI
Mroczek, Tomasz., Glowniak, Kazimierz., Wlaszczyk, Anna. Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography. Journal of chromatography a, 2002, vol. 949(1-2), p. 249-262.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature