Botanical species · safety record

Phellodendron amurense

The EFSA Compendium of Botanicals holds 74 constituent measurements for Phellodendron amurense. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Phellodendron amurense Rupr.

74Constituent measurements

0Safety records

8Cited sources

213Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 213 licensed products naming Phellodendron amurense as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
solid

Source material stated

Aged bark
Bark
Bark (Stir-baked with salt)
Bark extract
Branch bark
Cortex
Dried bark
Phellodendron amurense - root bark

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Bark	Solvent extraction	55 Microgram/gram	HPLC-DAD	Resolve DOI
Alkaloids	Stem / stalk	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Alkaloids	Bark	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Alkaloids	Bark	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Alkaloids	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Aporphine alkaloids	Stem / stalk	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Berberine	Bark	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Berberine	Stem / stalk	Solvent extraction	≥ 17.803 Microgram/gram	HPLC-DAD	Resolve DOI
Berberine	Bark	Solvent extraction	453 Microgram/gram	HPLC-DAD	Resolve DOI
Berberine	Stem / stalk	Solvent extraction	≤ 46.972 Microgram/gram	HPLC-DAD	Resolve DOI
Berberine	Bark	Solvent extraction	10.22 Milligram/gram	HPLC-MS/MS	Resolve DOI
Berberine	Bark	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Bisbenzylisoquinoline alkaloids	Stem / stalk	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Canadine	Stem / stalk	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Candicine	Bark	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Canthin-6-one	Bark	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Canthin-6-one	Bark	Solvent extraction	93 Microgram/gram	HPLC-DAD	Resolve DOI
Canthin-6-one	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Columbamine	Stem / stalk	Solvent extraction	≥ 0.1322 Microgram/gram	HPLC-DAD	Resolve DOI
Columbamine	Stem / stalk	Solvent extraction	≤ 0.5151 Microgram/gram	HPLC-DAD	Resolve DOI
Columbamine	Bark	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Coptisine	Bark	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Evodiamine	Stem / stalk	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Gamma fagarine	Stem / stalk	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Gamma fagarine	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Haplopine	Bark	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Isoquinoline alkaloids	Stem / stalk	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Isoquinoline alkaloids	Stem / stalk	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Jatrorrhizine	Stem / stalk	Solvent extraction	≥ 1.364 Microgram/gram	HPLC-DAD	Resolve DOI
Jatrorrhizine	Stem / stalk	Solvent extraction	≤ 3.134 Microgram/gram	HPLC-DAD	Resolve DOI
Jatrorrhizine	Bark	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Jatrorrhizine	Bark	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Limonin	Bark	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Limonin	Stem / stalk	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Limonin	Bark	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Limonin	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Limonoids	Bark	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Limonoids	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Magnocurarine	Stem / stalk	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Magnoflorine	Stem / stalk	Solvent extraction	≤ 10.353 Microgram/gram	HPLC-DAD	Resolve DOI

40 of 74 records are shown, ordered so that records carrying a resolvable reference come first.

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Akihisa, Toshihiro., Yokokawa, Satoru., Ogihara, Eri., Matsumoto, Masahiro., Zhang, Jie., Kikuchi, Takashi., Koike, Kazuo., Abe, Masahiko. Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark. . Chemistry & biodiversity, 2017, vol. 14, no. 7. DOI
Xian, Xiaoyan., Sun, Bohang., Ye, Xueting., Zhang, Guanying., Hou, Pengyi., Gao, Huiyuan. Identification and analysis of alkaloids in cortex Phellodendron amurense by high-performance liquid chromatography with electrospray ionization mass spectrometry coupled with photodiode array detection . Journal of separation science, 2014, vol. 37, no. 13, p. 1533-1545. DOI
Zhu, Shuang-lai., Dou, Sheng-shan., Liu, Xin-ru., Liu, Run-hui., Zhang, Wei-dong., Huang, Hong-lin., Zhang, Yi., Hu, Yao-hua., Wang, Shu-ping. Qualitative and quantitative analysis of alkaloids in Cortex Phellodendri by HPLC-ESI-MS/MS and HPLC-DAD. Chemical research in chinese universities, 2011, vol. 27, no. 1, p. 38-44.
Li, C. D., Liu, Y., Shi, Y. P. Simultaneous Determination of Six Alkaloids in Phellodendron amurense by High-Performance Liquid Chromatography . Acta chromatographica, 2013, vol. 25, no. 2, p. 275-285. DOI
Wu, W., Song, FR., Yan, CY., Liu, ZQ., Liu, SY. Structural analyses of protoberberine alkaloids in medicine herbs by using ESI--FT-ICR-MS and HPLC-ESI-MSn . Journal of pharmaceutical and biomedical analysis, 2005, vol. 37, no. 3, p. 437-446. DOI
Yang, Bo., Zhang, Xiaoying., Zhang, Rusong. A comparative study on analytical method of total alkaloids from cortex Phellodendri amurens by reversed phase high performance liquid chromatography (RP-HPLC) and pressurized capillary electrochromatography (pCEC) . Revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2011, vol. 21, no. 1, p. 16-23. DOI
Li, Yubo., Zhang, Tiejun., Zhang, Xiaolan., Xu, Haiyu., Liu, Changxiao. Chemical fingerprint analysis of Phellodendri Amurensis Cortex by ultra performance LC/Q-TOF-MS methods combined with chemometrics . Journal of separation science, 2010, vol. 33, no. 21, p. 3347-3353. DOI
Min, Yong Deuk., Kwon, Hak Cheol., Yang, Min Cheol., Lee, Kyu Ha., Choi, Sang Un., Lee, Kang Ro. Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance (MDR) reversal activity . Archives of pharmacal research, 2007, vol. 30, no. 1, p. 58-63. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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