Botanical species · safety record

Phyllanthus amarus

The EFSA Compendium of Botanicals holds 11 constituent measurements, 7 adverse-effect records and 1 genotoxicity assay for Phyllanthus amarus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Phyllanthus amarus Schumach. & Thonn.

11Constituent measurements

8Safety records

6Cited sources

16Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 16 licensed products naming Phyllanthus amarus as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Aerial parts
Herb
Leaf
Whole plant
Whole plant (extract)
Whole plant - Standardized extract
Whole plant(s)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Lignans	Unspecified	—	—	—	Resolve DOI
Alkaloids	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Alkaloids	Aerial part of plants	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Anthraquinones	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Anthraquinones	Aerial part of plants	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Cardenolides	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Naphthoquinones	Aerial part of plants	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Saponins	Aerial part of plants	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Saponins	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tannins	Aerial part of plants	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tannins	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive: pancreas	Live plants	Solvent extraction	—	In vitro	Resolve DOI
Hemopoietic	Cardiovascular / haematological	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Hemopoietic	Cardiovascular / haematological	Aerial part of plants	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Hepatotoxicity	Liver	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Nephrotoxicity	Liver	Aerial part of plants	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Reproductive	Testes	Aerial part of plants	Solvent extraction	House mouse (as animal)	Reproduction toxicity	No resolvable identifier
Reproductive	Testes	Aerial part of plants	Solvent extraction	House mouse (as animal)	Reproduction toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	micronucleus assay	House mouse (as animal)	Not applicable	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Bakare, A.A., Oguntolu, G.O., Adedokun, L.A., Amao, A.A., Oyeyemi, I.T., Alimba, C.G., Alabi, O.A. In vivo evaluation of genetic and systemic toxicity of aqueous extracts of phyllanthus amarus in mice and rats. International journal of toxicological and pharmacological research, 2015, vol. 7, no. 4.
Adedapo, Adeolu Alex., Abatan, Matthew Oluwole., Olorunsogo, Olufunso Olabode. Effects of some plants of the spurge family on haematological and biochemical parameters in rats . Veterinarski arhiv, 2007, vol. 77, no. 1, p. 29-38.
Trinh, Binh T. D., Staerk, Dan., Jager, Anna K. Screening for potential alpha-glucosidase and alpha-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes . Journal of ethnopharmacology, 2016, vol. 186, p. 189-195. DOI
Peters, D. E., Omeodu, S. I. Effect of ethanolic leave extract of phyllantus amarus on carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats. Journal of applied sciences and environmental management, 2015, vol. 19, no. 4, p. 803-808.
Nascimento, J. E., Melo, A. F. M., Lima e Silva, T. C., Veras Filho, J., Santos, E. M., Albuquerque, U. P., Amorim, E. L. C. Phytochemical screening and toxicological bioassay with brine shrimp larvae (Artemia salina Leach) of three medicinal species of the genus Phyllanthus (Phyllanthaceae) . Revista de ciencias farmaceuticas basica e aplicada, 2008, vol. 29, no. 2, p. 143-148.
Rajendra Prasad, N., Muthusamy, G., Shanmugam, M., Ambudkar, S.V. South asian medicinal compounds as modulators of resistance to chemotherapy and radiotherapy. Cancers, 2016, vol. 8, no. 3. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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