Botanical species · safety record

Physalis peruviana

The EFSA Compendium of Botanicals holds 26 constituent measurements and 3 adverse-effect records for Physalis peruviana. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Physalis peruviana L.

26Constituent measurements

3Safety records

12Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
1,8-cineole	Fruit unspecified	—	0.093 Microgram/100 gram	GC-MS	Resolve DOI
3alpha-tigloyloxytropane	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Alkaloids	Fruit unspecified	Raw, no heat treatment	1.31 Milligram/100 gram	Unspecified	Resolve DOI
Benzaldehyde	Fruit unspecified	—	58.5 Microgram/100 gram	GC-MS	Resolve DOI
Cardiac glycosides	Fruit unspecified	Raw, no heat treatment	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Cuscohygrine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Hygrine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Myrcene	Fruit unspecified	—	6.2 Microgram/100 gram	GC-MS	Resolve DOI
Phygrine	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Physoperuvine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Saponins	Fruit unspecified	Raw, no heat treatment	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Steroidal saponins	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Tropane alkaloids	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Tropane alkaloids	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Tropane alkaloids	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Tropine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Withanolides	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Withanolides	Unspecified	—	—	Unspecified	Resolve DOI
Withanolides	Aerial part of plants	Solvent extraction	2.2 Milligram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Withanolides	Fruit unspecified	Raw, no heat treatment	7.69 Milligram/100 gram	Unspecified	Resolve DOI
Withanolides	Aerial part of plants	Solvent extraction	1.6 Milligram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Withanolides	Aerial part of plants	Solvent extraction	2.9 Milligram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Withanolides	Aerial part of plants	Solvent extraction	6.9 Milligram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Withanolides	Fruit unspecified	Raw, no heat treatment	5.86 Milligram/100 gram	Unspecified	Resolve DOI
Physoperuvine	Roots and other underground parts	Solvent extraction	—	Unspecified	No resolvable identifier
Withanolides	Live plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
None	Urogenital: kidneys	Leaves	Powder	Guinea pig (as animal)	Acute toxicity	Resolve DOI
Systemic	Urogenital: kidneys	Leaves	Powder	Guinea pig (as animal)	Acute toxicity	Resolve DOI
Systemic	Heart	Fruit unspecified	Raw, no heat treatment	Rat (as animal)	Subchronic	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Xu, Ya-Ming., Wijeratne, E. M. Kithsiri., Babyak, Ashley L., Marks, Hanna R., Brooks, Alan D., Tewary, Poonam., Xuan, Li-Jiang., Wang, Wen-Qiong., Sayers, Thomas J., Gunatilaka, A. A. Leslie. Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells . Journal of natural products, 2017, vol. 80, no. 7, p. 1981-1991. DOI
KUBWABO, C., ROLLMANN, B., TILQUIN, B. ANALYSIS OF ALKALOIDS FROM PHYSALIS-PERUVIANA BY CAPILLARY GC, CAPILLARY GC-MS, AND GC-FTIR . Planta medica, 1993, vol. 59, no. 2, p. 161-163. DOI
Kasali, Felicien Mushagalusa., Kadima, Justin Ntokamunda., Mpiana, Pius Tshimankinda., Ngbolua, Koto-te-Nyiwa., Tshibangu, Damien Sha-Tshibey. Assessment of antidiabetic activity and acute toxicity of leaf extracts from Physalis peruviana L. in guinea-pig . Asian pacific journal of tropical biomedicine, 2013, vol. 3, no. 11, p. 841-846. DOI
Ahmad, S., Yasmin, R., Malik, A. New withanolide glycosides from Physalis peruviana L.. Chemical & pharmaceutical bulletin, 1999, vol. 47, no. 4, p. 477-480.
Lee, Chien-Chin., Chang, Wen-Hsin., Chang, Ya-Sian., Liu, Ting-Yuan., Chen, Yu-Chia., Wu, Yang-Chang., Chang, Jan-Gowth. 4 beta-Hydroxywithanolide E Modulates Alternative Splicing of Apoptotic Genes in Human Hepatocellular Carcinoma Huh-7 Cells . Scientific reports, 2017, vol. 7. DOI
Henrich, C. J., Brooks, A. D., Erickson, K. L., Thomas, C. L., Bokesch, H. R., Tewary, P., Thompson, C. R., Pompei, R. J., Gustafson, K. R., McMahon, J. B., Sayers, T. J. Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation . Cell death & disease, 2015, vol. 6. DOI
El-Gengaihi, Souad E., Hamed, Manal A., Khalaf-Allah, Abd El-Rahman M., Mohammed, Mona A. Golden Berry Juice Attenuates the Severity of Hepatorenal Injury. Journal of dietary supplements, 2013, vol. 10, no. 4, p. 357-369. DOI
Perk, Basak Ozlem., Ilgin, Sinem., Atli, Ozlem., Duymus, Hale Gamze., Sirmagul, Basar. Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L. . Evidence-based complementary and alternative medicine, 2013. DOI
BASEY, K., MCGAW, BA., WOOLLEY, JG. PHYGRINE, AN ALKALOID FROM PHYSALIS SPECIES. Phytochemistry, 1992, vol. 31, no. 12, p. 4173-4176. DOI
Arun, M., Asha, V. V. Preliminary studies on antihepatotoxic effect of Physalis peruviana Linn. (Solanaceae) against carbon tetrachloride induced acute liver injury in rats . Journal of ethnopharmacology, 2007, vol. 111, no. 1, p. 110-114. DOI
Ray, Anil B., Sahai, Mahendra., Sethi, Prabhu D. Physoperuvine, a new alkaloid of Physalis peruviana Linn. Chemistry & industry (london, united kingdom), 1976, vol. (10), p. 454-5.
Kupska, Magdalena., Jelen, Henryk H. In-tube extraction for the determination of the main volatile compounds in Physalis peruviana L . Journal of separation science, 2017, vol. 40, no. 2, p. 532-541. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature